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Article

VEGF Expression in Colorectal Cancer Metastatic Lymph Nodes: Clinicopathological Correlation and Prognostic Significance

1
Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga 4710-057, Portugal
2
ICVS/3B’s—PT Government Associate Laboratory, Braga/Guimarães 4710-057, Portugal
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Coloproctology Unit, Hospital de Braga, Braga 4710-243, Portugal
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Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo 14784-400, Brazil
5
Laboratory of Medical Investigation (LIM) 14, Faculty of Medicine, University of São Paulo, São Paulo 1246-903, Brazil
*
Author to whom correspondence should be addressed.
Gastrointest. Disord. 2020, 2(3), 267-280; https://0-doi-org.brum.beds.ac.uk/10.3390/gidisord2030025
Received: 14 June 2020 / Revised: 23 July 2020 / Accepted: 26 July 2020 / Published: 29 August 2020
Background: Angiogenesis plays an important role in colorectal cancer (CRC) tumorigenesis and metastatic progression. Methods: The present series consisted of CRC lymph node metastasis (LNM) tissue samples from 210 patients. Archival paraffin embedded LNM tissue were used to build up tissue microarray blocks and VEGF expression was immunohistochemically assessed. Results: VEGF-A and VEGF-C are overexpressed in LNM. VEGF-A was associated with patient age (p < 0.001), and VEGFR-2 and VEGFR-3 with CRC relapse (p = 0.032; p = 0.030, respectively). VEGF-C positivity was associated with VEGFR-3 positivity (p = 0.031), and VEGF-D with VEGFR-2 and VEGFR-3 (p ≤ 0.001). Matching the expression in LNM with CRC, in CRC VEGF-A positivity associates with VEGF-A, VEGF-C, VEGF-D, VEGF-R2, VEGF-R3 positivity in LNM; CRC VEGF-C with VEGF-D, VEGFR-2, VEGFR-3; CRC VEGFR-2 with VEGF-A, VEGF-C, VEGF-D, VEGFR-2, VEGFR-3; CRC VEGFR-3 with VEGF-A, VEGF-C, VEGF-D, VEGFR-2, VEGFR-3 in LNM. Conclusion: This study provides new information, revealing that VEGF family expression is increased in LNM. The association between the expression of VEGFR-2 and VEGFR-3 in LNM with CRC relapse reveals its impact on patient prognosis. Interesting data were found when the relationship between these proteins in primary tumor and their metastasis, were analyzed; VEGFA positivity in primary tumor is positively related to VEGF-A, VEGF-C, VEGF-D, VEGFR-2 and VEGFR-3 in their respective LNM suggesting mutual influence. View Full-Text
Keywords: colorectal cancer; lymph node metastasis; VEGF colorectal cancer; lymph node metastasis; VEGF
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MDPI and ACS Style

Mazeda, I.; Martins, S.F.; Garcia, E.A.; Rodrigues, M.; Longatto, A. VEGF Expression in Colorectal Cancer Metastatic Lymph Nodes: Clinicopathological Correlation and Prognostic Significance. Gastrointest. Disord. 2020, 2, 267-280. https://0-doi-org.brum.beds.ac.uk/10.3390/gidisord2030025

AMA Style

Mazeda I, Martins SF, Garcia EA, Rodrigues M, Longatto A. VEGF Expression in Colorectal Cancer Metastatic Lymph Nodes: Clinicopathological Correlation and Prognostic Significance. Gastrointestinal Disorders. 2020; 2(3):267-280. https://0-doi-org.brum.beds.ac.uk/10.3390/gidisord2030025

Chicago/Turabian Style

Mazeda, Inês, Sandra F. Martins, Eduardo A. Garcia, Mesquita Rodrigues, and Adhemar Longatto. 2020. "VEGF Expression in Colorectal Cancer Metastatic Lymph Nodes: Clinicopathological Correlation and Prognostic Significance" Gastrointestinal Disorders 2, no. 3: 267-280. https://0-doi-org.brum.beds.ac.uk/10.3390/gidisord2030025

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