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Review

The Effects of Iron Supplementation and Fortification on the Gut Microbiota: A Review

1
Faculty of Medicine, University of British Columbia, Vancouver, BC V6T 1Z3, Canada
2
Department of Food, Nutrition and Health, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
3
British Columbia Children’s Hospital Research Institute, Vancouver, BC V5Z 4H4, Canada
4
Department of Pathology and Laboratory Medicine, BC Children’s and Women’s Hospital and University of British Columbia, Vancouver, BC V6T 1Z7, Canada
*
Author to whom correspondence should be addressed.
Gastrointest. Disord. 2020, 2(4), 327-340; https://0-doi-org.brum.beds.ac.uk/10.3390/gidisord2040030
Received: 30 August 2020 / Revised: 22 September 2020 / Accepted: 24 September 2020 / Published: 26 September 2020
Iron supplementation and fortification are used to treat iron deficiency, which is often associated with gastrointestinal conditions, such as inflammatory bowel disease and colorectal cancer. Within the gut, commensal bacteria contribute to maintaining systemic iron homeostasis. Disturbances that lead to excess iron promote the replication and virulence of enteric pathogens. Consequently, research has been interested in better understanding the effects of iron supplementation and fortification on gut bacterial composition and overall gut health. While animal and human trials have shown seemingly conflicting results, these studies emphasize how numerous factors influence gut microbial composition. Understanding how different iron formulations and doses impact specific bacteria will improve the outcomes of iron supplementation and fortification in humans. Furthermore, discerning the nuances of iron supplementation and fortification will benefit subpopulations that currently do not respond well to treatment. View Full-Text
Keywords: iron supplementation; gut microbiome; iron metabolism; gastrointestinal homeostasis iron supplementation; gut microbiome; iron metabolism; gastrointestinal homeostasis
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MDPI and ACS Style

Finlayson-Trick, E.C.; Fischer, J.A.; Goldfarb, D.M.; Karakochuk, C.D. The Effects of Iron Supplementation and Fortification on the Gut Microbiota: A Review. Gastrointest. Disord. 2020, 2, 327-340. https://0-doi-org.brum.beds.ac.uk/10.3390/gidisord2040030

AMA Style

Finlayson-Trick EC, Fischer JA, Goldfarb DM, Karakochuk CD. The Effects of Iron Supplementation and Fortification on the Gut Microbiota: A Review. Gastrointestinal Disorders. 2020; 2(4):327-340. https://0-doi-org.brum.beds.ac.uk/10.3390/gidisord2040030

Chicago/Turabian Style

Finlayson-Trick, Emma C., Jordie A. Fischer, David M. Goldfarb, and Crystal D. Karakochuk 2020. "The Effects of Iron Supplementation and Fortification on the Gut Microbiota: A Review" Gastrointestinal Disorders 2, no. 4: 327-340. https://0-doi-org.brum.beds.ac.uk/10.3390/gidisord2040030

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