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Review

Obesity and Related Type 2 Diabetes: A Failure of the Autonomic Nervous System Controlling Gastrointestinal Function?

Centro Diabete, Ospedale Sandro Pertini-ASLRMB, Largo T. Solera n.10, 00199 Rome, Italy
Gastrointest. Disord. 2020, 2(4), 423-447; https://0-doi-org.brum.beds.ac.uk/10.3390/gidisord2040039
Received: 20 October 2020 / Accepted: 29 October 2020 / Published: 1 November 2020
The pandemic spread of obesity and type 2 diabetes is a serious health problem that cannot be contained with common therapies. At present, the most effective therapeutic tool is metabolic surgery, which substantially modifies the gastrointestinal anatomical structure. This review reflects the state of the art research in obesity and type 2 diabetes, describing the probable reason for their spread, how the various brain sectors are involved (with particular emphasis on the role of the vagal system controlling different digestive functions), and the possible mechanisms for the effectiveness of bariatric surgery. According to the writer’s interpretation, the identification of drugs that can modulate the activity of some receptor subunits of the vagal neurons and energy-controlling structures of the central nervous system (CNS), and/or specific physical treatment of cortical areas, could reproduce, non-surgically, the positive effects of metabolic surgery. View Full-Text
Keywords: GI role in energy homeostasis; obesity pathogenesis; obesity therapy; metabolic surgery mechanism; vagal control of GI function; NMDA receptors; pharmacotherapy of obesity GI role in energy homeostasis; obesity pathogenesis; obesity therapy; metabolic surgery mechanism; vagal control of GI function; NMDA receptors; pharmacotherapy of obesity
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MDPI and ACS Style

Blasi, C. Obesity and Related Type 2 Diabetes: A Failure of the Autonomic Nervous System Controlling Gastrointestinal Function? Gastrointest. Disord. 2020, 2, 423-447. https://0-doi-org.brum.beds.ac.uk/10.3390/gidisord2040039

AMA Style

Blasi C. Obesity and Related Type 2 Diabetes: A Failure of the Autonomic Nervous System Controlling Gastrointestinal Function? Gastrointestinal Disorders. 2020; 2(4):423-447. https://0-doi-org.brum.beds.ac.uk/10.3390/gidisord2040039

Chicago/Turabian Style

Blasi, Claudio. 2020. "Obesity and Related Type 2 Diabetes: A Failure of the Autonomic Nervous System Controlling Gastrointestinal Function?" Gastrointestinal Disorders 2, no. 4: 423-447. https://0-doi-org.brum.beds.ac.uk/10.3390/gidisord2040039

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