Next Article in Journal
Disease-Related Knowledge in New Zealand Children with Inflammatory Bowel Disease (IBD) and Their Parents
Next Article in Special Issue
Clinical Impact of Sarcopenia on Gastrointestinal Tumors
Previous Article in Journal / Special Issue
Assessment of Current Gene Therapy Practices in Hepatocellular Carcinoma
Review

Role of Her-2 in Gastrointestinal Tumours beyond Gastric Cancer: A Tool for Precision Medicine

1
Head and Neck Surgery, National Institute of Oncology, 1122 Budapest, Hungary
2
Medical Oncology Department, Shaqlawa Teaching Hospital, Erbil 44001, Iraq
3
Department of Clinical Oncology, BINOR Cancer Hospital, Bannu 28100, Pakistan
4
Cancer Biomarkers Working Group, Oujda 60000, Morocco
5
Oncomédica C.A., Caracas 1060, Venezuela
6
Northwest Cancer Center, Western Health and Social Care Trust, Altnagelvin Hospital, Londonderry BT47 6SB, UK
7
UT Southwestern Clements University Hospital, Dallas, TX 75390, USA
8
European Institute of Oncology, IRCCS, 20141 Milan, Italy
9
Medical Oncology Unit, Ospedale del Mare, 80147 Naples, Italy
10
Division of Medical Oncology, Department of Precision Medicine, School of Medicine, University of Study of Campania “L.Vanvitelli”, 81100 Caserta, Italy
*
Author to whom correspondence should be addressed.
Gastrointest. Disord. 2021, 3(1), 1-22; https://0-doi-org.brum.beds.ac.uk/10.3390/gidisord3010001
Received: 11 November 2020 / Revised: 7 December 2020 / Accepted: 17 December 2020 / Published: 22 December 2020
Gastrointestinal (GI) tumors account for a quarter of all the cancer burden and a third of the global cancer-related mortality. Among them, some cancers retain a dismal prognosis; therefore, newer and innovative therapies are urgently needed in priority disease areas of high-unmet medical need. In this context, HER2 could be a relevant prognostic and predictive biomarker acting as a target for specific drugs. However, if the role of HER2 has been object of investigation for several years in gastric cancer, it is not well established in other GI malignancies. The aim of this narrative review was to portray the current landscape of the potential role of HER2 as a predictive biomarker for GI tumors beyond gastric cancer. In colon cancer, the benefit from anti-HER2 therapies is less clear than in gastric neoplasms for the lack of controlled studies. Pancreatic, biliary tract adenocarcinomas and hepatocarcinoma may derive a less clear clinical benefit by using anti-HER2 agents in HER2 positive tumors. Overall, the results are promising and seem to suggest that the integration of multiple modalities of therapies can optimize the cancer care. However, further prospective trials are needed to validate the use of personalized targeted therapies in this field. View Full-Text
Keywords: biliary cancer; colorectal cancer; cholangiocarcinoma; prognostic factor; predictive; GIST; precision medicine; target therapy; metastatic cancer biliary cancer; colorectal cancer; cholangiocarcinoma; prognostic factor; predictive; GIST; precision medicine; target therapy; metastatic cancer
MDPI and ACS Style

Lengyel, C.G.; Habeeb, B.; Khan, S.Z.; El Bairi, K.; Altuna, S.C.; Hussain, S.; Mazher, S.A.; Trapani, D.; Petrillo, A. Role of Her-2 in Gastrointestinal Tumours beyond Gastric Cancer: A Tool for Precision Medicine. Gastrointest. Disord. 2021, 3, 1-22. https://0-doi-org.brum.beds.ac.uk/10.3390/gidisord3010001

AMA Style

Lengyel CG, Habeeb B, Khan SZ, El Bairi K, Altuna SC, Hussain S, Mazher SA, Trapani D, Petrillo A. Role of Her-2 in Gastrointestinal Tumours beyond Gastric Cancer: A Tool for Precision Medicine. Gastrointestinal Disorders. 2021; 3(1):1-22. https://0-doi-org.brum.beds.ac.uk/10.3390/gidisord3010001

Chicago/Turabian Style

Lengyel, Csongor G., Baker Habeeb, Shah Z. Khan, Khalid El Bairi, Sara C. Altuna, Sadaqat Hussain, Syed A. Mazher, Dario Trapani, and Angelica Petrillo. 2021. "Role of Her-2 in Gastrointestinal Tumours beyond Gastric Cancer: A Tool for Precision Medicine" Gastrointestinal Disorders 3, no. 1: 1-22. https://0-doi-org.brum.beds.ac.uk/10.3390/gidisord3010001

Find Other Styles

Article Access Map by Country/Region

1
Back to TopTop