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Development of a Motility Frailty Index in Patients with Gastroparesis

Division of Gastroenterology, Hepatology, and Nutrition, University of Louisville, Louisville, KY 40292, USA
Department of Bioinformatics and Biostatistics, School of Public Health and Information Sciences, University of Louisville, Louisville, KY 40292, USA
Author to whom correspondence should be addressed.
Academic Editor: Takuji Tanaka
Gastrointest. Disord. 2021, 3(2), 78-83;
Received: 13 February 2021 / Revised: 2 April 2021 / Accepted: 22 April 2021 / Published: 25 April 2021
Introduction: Patients with symptoms (Sx) of gastrointestinal (GI) motor disorders have limitations in physical strength and mobility. We hypothesized that physical frailty correlated with severity of GI symptoms, and that a motility frailty index (MFI) could be constructed. Patients: We conducted a prospective pilot study on 40 patients, (38 F, 2 M, mean age 39.9 years) with the following diagnoses: 10 with diabetes mellitus and 30 with non-diabetic/idiopathic disorders. Upper and lower GI Sx were quantified using an FDA-compliant, traditional patient-reported outcomes (PRO) system. Methods: Patients underwent a series of physical performance measures involving standing balance (SB), usual walk speed (UW), and chair sit-and-stands (CS). A GI motility frailty index (MFI) was constructed by fitting several models with a combination of physical performance measures and correlating with PRO. Pearson’s correlation compared the constructed index with the GI Sx PRO to construct a GI MFI. Results: The studied patients collectively showed marked limitations in mobility compared with standard performance values with mean (sd) ratios of SB = 0.87 (0.20), UW = 0.45 (0.13), and CS = 0.38 (0.17). Correlations between physical mobility and GI Sx were noted for upper GI Sx (rho = 0.47, p = 0.002) but not for lower GI Sx. Conclusions: In this pilot study of patients with GI motility disorders, we found increased physical limitations on performance-based testing, which had a statistically significant positive correlation with severity of upper GI motor Sx using a standardized PRO system. A motility frailty index has been constructed that may serve as a basis for better quantifying limitations in patient mobility. View Full-Text
Keywords: gastroparesis; motility; diabetes; mobility; frailty gastroparesis; motility; diabetes; mobility; frailty
MDPI and ACS Style

Winston, J.; Guzman Rojas, P.; Stocker, A.; Mathur, P.; Lorenz, D.; Daniels, M.; Abell, T. Development of a Motility Frailty Index in Patients with Gastroparesis. Gastrointest. Disord. 2021, 3, 78-83.

AMA Style

Winston J, Guzman Rojas P, Stocker A, Mathur P, Lorenz D, Daniels M, Abell T. Development of a Motility Frailty Index in Patients with Gastroparesis. Gastrointestinal Disorders. 2021; 3(2):78-83.

Chicago/Turabian Style

Winston, Jared, Patricia Guzman Rojas, Abigail Stocker, Prateek Mathur, Douglas Lorenz, Michael Daniels, and Thomas Abell. 2021. "Development of a Motility Frailty Index in Patients with Gastroparesis" Gastrointestinal Disorders 3, no. 2: 78-83.

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