An increasing amount of landslides leading to significant human and economic consequences is a primary concern for the government of Tajikistan and local authorities. Based on the Committee on Emergency Situations data, from 1996 to 2018, there were 3460 emergencies and more than 1000 fatalities because of earthquake-triggered and rainfall-induced landslides in the region. In addition, landslides caused severe damage to houses and infrastructure facilities due to the population’s lack of landslide hazard knowledge. Therefore, current research focuses on developing a regional-scale landslide inventory map in the Hissar–Allay region, central Tajikistan, where the population density is much higher than at other mountainous territories. In recent decades, the enhancements in geographic information systems, the open access to high-resolution remote sensing data, and an extensive field survey allowed us to identify 922 landslides possible along the highway corridor in the Hissar–Allay region. Based on Varnes’s system, these landslides are classified into four categories: debris flows, rockfalls, shallow landslides, and complex (deep-seated) landslides, considering landslides morphology, geology, deformation of slopes, degree and aspect of slopes, and weathered and disintegrated zones on slopes in the study area. The results show that 8.24% of the total study area is affected by landslides. Along the highway corridor in the Hissar–Allay region there are 96 bodies of deep-seated landslides and 216 rockfall catchments, 273 debris flow catchments, and 313 shallow landslides. Thus, shallow landslides are the most frequent type of movement. In addition, landslide frequency-area distribution analysis shows that shallow landslides are frequent with an area of 1.88E+04 m2
; most frequent debris flow channels have a place of 5.58E+05 m2
; rockfalls, for its part, are rife with an area of 1.50E+05 m2
, and frequent complex landslides have an area of 4.70E+06 m2
. Furthermore, it was found out that slopes consist of Silurian formation comprise shales, pebbles, sands, loams, and limestones, metamorphic clays are exposed to landslides more than other geological formations because of the layered structure and their broad spatial distribution in the study area. As the first applied research to compile a landslide inventory map in the Hissar–Allay region on the regional scale, our study provides a sound basis for future explorations of landslide susceptibility, hazard, and risk assessment for this region.