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Experimental Hypomagnesemia Induces Neurogenic Inflammation and Cardiac Dysfunction

1
Department of Biochemistry & Molecular Medicine, The George Washington University, Washington, DC 20037, USA
2
Division of Cardiology, Children’s National Medical Center, Washington, DC 20010, USA
3
Affiliate Professor of Pharmaceutics, Virginia Commonwealth University, Richmond, VA 23284, USA
*
Authors to whom correspondence should be addressed.
Received: 23 July 2020 / Revised: 2 September 2020 / Accepted: 2 September 2020 / Published: 5 September 2020
(This article belongs to the Special Issue Nutrient Deficiency and Drug Induced Cardiac Injury and Dysfunction)
Hypomagnesemia occurs clinically as a result of restricted dietary intake, Mg-wasting drug therapies, chronic disease status and may be a risk factor in patients with cardiovascular disorders. Dietary restriction of magnesium (Mg deficiency) in animal models produced a pro-inflammatory/pro-oxidant condition, involving hematopoietic, neuronal, cardiovascular, renal and other systems. In Mg-deficient rodents, early elevations in circulating levels of the neuropeptide, substance P (SP) may trigger subsequent deleterious inflammatory/oxidative/nitrosative stress events. Evidence also suggests that activity of neutral endopeptidase (NEP, neprilysin), the major SP-degrading enzyme, may be impaired during later stages of Mg deficiency, and this may sustain the neurogenic inflammatory response. In this article, experimental findings using substance P receptor blockade, NEP inhibition, and N-methyl-D-aspartate (NMDA) receptor blockade demonstrated the connection between hypomagnesemia, neurogenic inflammation, oxidative stress and enhanced cardiac dysfunction. Proof of concept concerning neurogenic inflammation is provided using an isolated perfused rat heart model exposed to acute reductions in perfusate magnesium concentrations. View Full-Text
Keywords: magnesium deficiency; substance P and substance P receptor blockade; neutral endopeptidase inhibition; NMDA receptor blockade; inflammatory cytokines; oxidative/nitrosative stress; neutrophil superoxide generation; RBC glutathione; cardiac dysfunction; perfused rat heart model magnesium deficiency; substance P and substance P receptor blockade; neutral endopeptidase inhibition; NMDA receptor blockade; inflammatory cytokines; oxidative/nitrosative stress; neutrophil superoxide generation; RBC glutathione; cardiac dysfunction; perfused rat heart model
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MDPI and ACS Style

Kramer, J.H.; Mak, I.T.; Chmielinska, J.J.; Spurney, C.F.; Phillips, T.M.; Weglicki, W.B. Experimental Hypomagnesemia Induces Neurogenic Inflammation and Cardiac Dysfunction. Hearts 2020, 1, 99-116. https://0-doi-org.brum.beds.ac.uk/10.3390/hearts1020011

AMA Style

Kramer JH, Mak IT, Chmielinska JJ, Spurney CF, Phillips TM, Weglicki WB. Experimental Hypomagnesemia Induces Neurogenic Inflammation and Cardiac Dysfunction. Hearts. 2020; 1(2):99-116. https://0-doi-org.brum.beds.ac.uk/10.3390/hearts1020011

Chicago/Turabian Style

Kramer, Jay H.; Mak, I. T.; Chmielinska, Joanna J.; Spurney, Christopher F.; Phillips, Terry M.; Weglicki, William B. 2020. "Experimental Hypomagnesemia Induces Neurogenic Inflammation and Cardiac Dysfunction" Hearts 1, no. 2: 99-116. https://0-doi-org.brum.beds.ac.uk/10.3390/hearts1020011

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