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Vitamin A as a Transcriptional Regulator of Cardiovascular Disease

Drug Research Program, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, 00790 Helsinki, Finland
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Received: 28 August 2020 / Revised: 17 September 2020 / Accepted: 17 September 2020 / Published: 21 September 2020
(This article belongs to the Special Issue Nutrient Deficiency and Drug Induced Cardiac Injury and Dysfunction)
Vitamin A is a micronutrient and signaling molecule that regulates transcription, cellular differentiation, and organ homeostasis. Additionally, metabolites of Vitamin A are utilized as differentiation agents in the treatment of hematological cancers and skin disorders, necessitating further study into the effects of both nutrient deficiency and the exogenous delivery of Vitamin A and its metabolites on cardiovascular phenotypes. Though vitamin A/retinoids are well-known regulators of cardiac formation, recent evidence has emerged that supports their role as regulators of cardiac regeneration, postnatal cardiac function, and cardiovascular disease progression. We here review findings from genetic and pharmacological studies describing the regulation of both myocyte- and vascular-driven cardiac phenotypes by vitamin A signaling. We identify the relationship between retinoids and maladaptive processes during the pathological hypertrophy of the heart, with a focus on the activation of neurohormonal signaling and fetal transcription factors (Gata4, Tbx5). Finally, we assess how this information might be leveraged to develop novel therapeutic avenues. View Full-Text
Keywords: micronutrient; heart failure; vitamin A; retinoid; nuclear receptor; cardiomyocyte; cardiac regeneration micronutrient; heart failure; vitamin A; retinoid; nuclear receptor; cardiomyocyte; cardiac regeneration
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MDPI and ACS Style

Leigh, R.S.; Kaynak, B.L. Vitamin A as a Transcriptional Regulator of Cardiovascular Disease. Hearts 2020, 1, 126-145. https://0-doi-org.brum.beds.ac.uk/10.3390/hearts1020013

AMA Style

Leigh RS, Kaynak BL. Vitamin A as a Transcriptional Regulator of Cardiovascular Disease. Hearts. 2020; 1(2):126-145. https://0-doi-org.brum.beds.ac.uk/10.3390/hearts1020013

Chicago/Turabian Style

Leigh, Robert S.; Kaynak, Bogac L. 2020. "Vitamin A as a Transcriptional Regulator of Cardiovascular Disease" Hearts 1, no. 2: 126-145. https://0-doi-org.brum.beds.ac.uk/10.3390/hearts1020013

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