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Functional Hypothalamic Amenorrhea: A Stress-Based Disease

Department of Gynecological Endocrinology, Poznan University of Medical Sciences, 60-701 Poznan, Poland
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Author to whom correspondence should be addressed.
Academic Editor: Antonio Brunetti
Received: 20 June 2021 / Revised: 14 July 2021 / Accepted: 22 July 2021 / Published: 24 July 2021
The aim of the study is to present the problem of functional hypothalamic amenorrhea, taking into account any disease and treatment, diagnosis, and consequences of this disease. We searched PubMed (MEDLINE) and included 38 original and review articles concerning functional hypothalamic amenorrhea. Functional hypothalamic amenorrhea is the most common cause of secondary amenorrhea in women of childbearing age. It is a reversible disorder caused by stress related to weight loss, excessive exercise and/or traumatic mental experiences. The basis of functional hypothalamic amenorrhea is hormonal, based on impaired pulsatile GnRH secretion in the hypothalamus, then decreased secretion of gonadotropins, and, consequently, impaired hormonal function of the ovaries. This disorder leads to hypoestrogenism, manifested by a disturbance of the menstrual cycle in the form of amenorrhea, leading to anovulation. Prolonged state of hypoestrogenism can be very detrimental to general health, leading to many harmful short- and long-term consequences. Treatment of functional hypothalamic amenorrhea should be started as soon as possible, and it should primarily involve lifestyle modification. Only then should pharmacological treatment be applied. Importantly, treatment is most often long-term, but it results in recovery for the majority of patients. Effective therapy, based on multidirectional action, can protect patients from numerous negative impacts on fertility, cardiovascular system and bone health, as well as reducing mental morbidity. View Full-Text
Keywords: functional hypothalamic amenorrhea; weight loss; exercise; stress-induced amenorrhea; bone mineral density; cardiovascular system functional hypothalamic amenorrhea; weight loss; exercise; stress-induced amenorrhea; bone mineral density; cardiovascular system
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MDPI and ACS Style

Podfigurna, A.; Meczekalski, B. Functional Hypothalamic Amenorrhea: A Stress-Based Disease. Endocrines 2021, 2, 203-211. https://0-doi-org.brum.beds.ac.uk/10.3390/endocrines2030020

AMA Style

Podfigurna A, Meczekalski B. Functional Hypothalamic Amenorrhea: A Stress-Based Disease. Endocrines. 2021; 2(3):203-211. https://0-doi-org.brum.beds.ac.uk/10.3390/endocrines2030020

Chicago/Turabian Style

Podfigurna, Agnieszka, and Blazej Meczekalski. 2021. "Functional Hypothalamic Amenorrhea: A Stress-Based Disease" Endocrines 2, no. 3: 203-211. https://0-doi-org.brum.beds.ac.uk/10.3390/endocrines2030020

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