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Article

Impact of 1.0 mg/Day Dienogest Treatment on Bone Metabolism Markers in Young Women with Dysmenorrhea

1
Department of Gynecology, Kurashiki Heisei Hospital, Kurashiki 710-0826, Japan
2
Department of Gynecologic Oncology, Kawasaki Medical School, Kurashiki 701-0192, Japan
3
Department of Obstetrics and Gynecology, Faculty of Medicine, Tottori University, Yonago 683-8504, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Maria Felicia Faienza
Received: 27 May 2021 / Revised: 28 July 2021 / Accepted: 19 August 2021 / Published: 26 August 2021
(This article belongs to the Special Issue Impact of Endometriosis on Women’s Health)
A low dose of dienogest (DNG) 1 mg/day is useful for treating dysmenorrhea in young women. However, the effect of DNG on bone turnover during bone growth and formation, rather than at maturity, is currently unknown even at low doses. We investigated change in bone turnover after 3 months of DNG 1 mg/day. This retrospective cohort study included young women aged 10–24 years with dysmenorrhea and irregular menstruation. Gonadotropins and the bone metabolism markers TRACP-5b and BAP were compared before and at 3 months after administration of DNG 1 mg/day. There were no significant changes in TRACP-5b (before, 455.6 ± 323.6 mU/dL; 3 months after, 462.1 ± 346.1 mU/dL), BAP (before, 24.7 ± 19.0 μg/L; 3 months after, 25.2 ± 22.3 μg/L), or the TRACP-5b/BAP ratio (before, 22.1 ± 7.0; 3 months after, 21.5 ± 6.3). Administration of DNG 1 mg/day had no significant effect on bone turnover after 3 months during the bone-growth phase in young women. View Full-Text
Keywords: dienogest; dysmenorrhea; adolescent; bone metabolism markers dienogest; dysmenorrhea; adolescent; bone metabolism markers
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MDPI and ACS Style

Ota, I.; Ota, Y.; Taniguchi, F. Impact of 1.0 mg/Day Dienogest Treatment on Bone Metabolism Markers in Young Women with Dysmenorrhea. Endocrines 2021, 2, 293-300. https://0-doi-org.brum.beds.ac.uk/10.3390/endocrines2030027

AMA Style

Ota I, Ota Y, Taniguchi F. Impact of 1.0 mg/Day Dienogest Treatment on Bone Metabolism Markers in Young Women with Dysmenorrhea. Endocrines. 2021; 2(3):293-300. https://0-doi-org.brum.beds.ac.uk/10.3390/endocrines2030027

Chicago/Turabian Style

Ota, Ikuko, Yoshiaki Ota, and Fuminori Taniguchi. 2021. "Impact of 1.0 mg/Day Dienogest Treatment on Bone Metabolism Markers in Young Women with Dysmenorrhea" Endocrines 2, no. 3: 293-300. https://0-doi-org.brum.beds.ac.uk/10.3390/endocrines2030027

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