Next Article in Journal / Special Issue
A Review of the Synthetic Strategies toward Dihydropyrrolo[1,2-a]Pyrazinones
Previous Article in Journal
MCR under Microwave Irradiation: Synthesis in Water of New 2-Amino-bis(2-phosphonoacetic) Acids
Previous Article in Special Issue
Pd-Based Polysaccharide Hydrogels as Heterogeneous Catalysts for Oxidation of Aromatic Alcohols
Article

A Sustainable Improvement of ω-Bromoalkylphosphonates Synthesis to Access Novel KuQuinones

1
Department of Chemical Science and Technologies, University of Rome Tor Vergata, Via della Ricerca Scientifica snc, 00133 Rome, Italy
2
Department of Molecular Sciences and Nanosystems, Ca’ Foscari University of Venezia, Via Torino 155, 30172 Venezia, Italy
*
Authors to whom correspondence should be addressed.
Academic Editor: Wim Dehaen
Received: 28 April 2021 / Revised: 24 May 2021 / Accepted: 1 June 2021 / Published: 3 June 2021
(This article belongs to the Special Issue Feature Papers in Organics)
Owing to the attractiveness of organic phosphonic acids and esters in the pharmacological field and in the functionalization of conductive metal-oxides, the research of effective synthetic protocols is pivotal. Among the others, ω-bromoalkylphosphonates are gaining particular attention because they are useful building blocks for the tailored functionalization of complex organic molecules. Hence, in this work, the optimization of Michaelis–Arbuzov reaction conditions for ω-bromoalkylphosphonates has been performed, to improve process sustainability while maintaining good yields. Synthesized ω-bromoalkylphosphonates have been successfully adopted for the synthesis of new KuQuinone phosphonate esters and, by hydrolysis, phosphonic acid KuQuinone derivatives have been obtained for the first time. Considering the high affinity with metal-oxides, KuQuinones bearing phosphonic acid terminal groups are promising candidates for biomedical and photo(electro)chemical applications. View Full-Text
Keywords: ω-bromoalkylphosphonates; KuQuinones; phosphonate esters; diethyl phosphonates; organic phosphonic acids; Arbuzov reaction; triethyl phosphite; phosphonate ester hydrolysis; dibromoalkane; anchoring group ω-bromoalkylphosphonates; KuQuinones; phosphonate esters; diethyl phosphonates; organic phosphonic acids; Arbuzov reaction; triethyl phosphite; phosphonate ester hydrolysis; dibromoalkane; anchoring group
Show Figures

Figure 1

MDPI and ACS Style

Forchetta, M.; Conte, V.; Fiorani, G.; Galloni, P.; Sabuzi, F. A Sustainable Improvement of ω-Bromoalkylphosphonates Synthesis to Access Novel KuQuinones. Organics 2021, 2, 107-117. https://0-doi-org.brum.beds.ac.uk/10.3390/org2020010

AMA Style

Forchetta M, Conte V, Fiorani G, Galloni P, Sabuzi F. A Sustainable Improvement of ω-Bromoalkylphosphonates Synthesis to Access Novel KuQuinones. Organics. 2021; 2(2):107-117. https://0-doi-org.brum.beds.ac.uk/10.3390/org2020010

Chicago/Turabian Style

Forchetta, Mattia, Valeria Conte, Giulia Fiorani, Pierluca Galloni, and Federica Sabuzi. 2021. "A Sustainable Improvement of ω-Bromoalkylphosphonates Synthesis to Access Novel KuQuinones" Organics 2, no. 2: 107-117. https://0-doi-org.brum.beds.ac.uk/10.3390/org2020010

Find Other Styles

Article Access Map by Country/Region

1
Back to TopTop