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Review

A Review of the Synthetic Strategies toward Dihydropyrrolo[1,2-a]Pyrazinones

1
Molecular Design and Synthesis, Department of Chemistry, KU Leuven, Celestijnenlaan 200F, 3001 Leuven, Belgium
2
Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences at Ribeirao Preto of the University of Sao Paulo, Ribeirao Preto 14040903, SP, Brazil
*
Authors to whom correspondence should be addressed.
Both authors contributed equally to this work.
Academic Editor: David StC Black
Received: 11 May 2021 / Revised: 27 May 2021 / Accepted: 2 June 2021 / Published: 4 June 2021
(This article belongs to the Special Issue Feature Papers in Organics)
Dihydropyrrolo[1,2-a]pyrazinone rings are a class of heterocycles present in a wide range of bioactive natural products and analogues thereof. As a direct result of their bioactivity, the synthesis of this privileged class of compounds has been extensively studied. This review provides an overview of these synthetic pathways. The literature is covered up until 2020 and is organized according to the specific strategies used to construct the scaffold: fusing a pyrazinone to an existing pyrrole, employing a pyrazinone-first strategy, an array of multicomponent reactions and some miscellaneous reactions. View Full-Text
Keywords: pyrrole; pyrazinone; heterocycle; natural product; cycloaddition; multicomponent reaction pyrrole; pyrazinone; heterocycle; natural product; cycloaddition; multicomponent reaction
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MDPI and ACS Style

Winant, P.; Horsten, T.; Gil de Melo, S.M.; Emery, F.; Dehaen, W. A Review of the Synthetic Strategies toward Dihydropyrrolo[1,2-a]Pyrazinones. Organics 2021, 2, 118-141. https://0-doi-org.brum.beds.ac.uk/10.3390/org2020011

AMA Style

Winant P, Horsten T, Gil de Melo SM, Emery F, Dehaen W. A Review of the Synthetic Strategies toward Dihydropyrrolo[1,2-a]Pyrazinones. Organics. 2021; 2(2):118-141. https://0-doi-org.brum.beds.ac.uk/10.3390/org2020011

Chicago/Turabian Style

Winant, Pieterjan, Tomas Horsten, Shaiani M. Gil de Melo, Flavio Emery, and Wim Dehaen. 2021. "A Review of the Synthetic Strategies toward Dihydropyrrolo[1,2-a]Pyrazinones" Organics 2, no. 2: 118-141. https://0-doi-org.brum.beds.ac.uk/10.3390/org2020011

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