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MCR under Microwave Irradiation: Synthesis in Water of New 2-Amino-bis(2-phosphonoacetic) Acids

Normandie Université, France, ENSICAEN, LCMT, UMR CNRS 6507, INC3M, FR 3038, Labex EMC3, Labex SynOrg, 14050 Caen, France
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Academic Editor: Tomasz K. Olszewski
Received: 23 March 2021 / Revised: 13 April 2021 / Accepted: 28 April 2021 / Published: 11 May 2021
Novel 2-amino bis(2-phosphonoacetic) acids were prepared by microwave irradiation of a mixture of amine, glyoxylic acid and phosphorous acid. The reaction takes place with various amines including primary and secondary amines and polyamines, but this reaction is more sensitive to steric hindrance of amine than the similar Kabachnik–Fields reaction. Amino acids can be also transformed into the expected bis(2-phosphonoacetic) acids, with the exception of tryptophan, which gives a β-carboline product. View Full-Text
Keywords: multicomponent reaction (MCR); aminophosphonic acetic acid; green conditions; microwave irradiation multicomponent reaction (MCR); aminophosphonic acetic acid; green conditions; microwave irradiation
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MDPI and ACS Style

Villemin, D.; Moreau, B.; Bar, N. MCR under Microwave Irradiation: Synthesis in Water of New 2-Amino-bis(2-phosphonoacetic) Acids. Organics 2021, 2, 98-106. https://0-doi-org.brum.beds.ac.uk/10.3390/org2020009

AMA Style

Villemin D, Moreau B, Bar N. MCR under Microwave Irradiation: Synthesis in Water of New 2-Amino-bis(2-phosphonoacetic) Acids. Organics. 2021; 2(2):98-106. https://0-doi-org.brum.beds.ac.uk/10.3390/org2020009

Chicago/Turabian Style

Villemin, Didier, Bernard Moreau, and Nathalie Bar. 2021. "MCR under Microwave Irradiation: Synthesis in Water of New 2-Amino-bis(2-phosphonoacetic) Acids" Organics 2, no. 2: 98-106. https://0-doi-org.brum.beds.ac.uk/10.3390/org2020009

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