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The Role of Cathepsins in the Growth of Primary and Secondary Neoplasia in the Bone

Department of Radiation Oncology, University of Florida, Gainesville, FL 32610, USA
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Received: 20 August 2020 / Revised: 21 September 2020 / Accepted: 23 September 2020 / Published: 9 October 2020
The upregulation of proteolytic enzymes has been demonstrated to promote primary tumor development and metastatic bone cancer. The secreted proteases increase tumor growth and angiogenesis, and potentiate neoplastic cell dissemination. This article reviews the role and mechanisms of cathepsins in normal physiology, cancer, bone remodeling, and the tumor–bone interface, with a specific focus on cathepsins B, D, H, G, L, and K. In this review, we highlight the role of cathepsins in primary bone cancer (i.e., osteosarcoma (OS)), as well as metastatic breast (BCa) and prostate (PCa) cancer. In addition, we discuss the clinical utility and therapeutic potential of cathepsin-targeted treatments in primary and secondary bone cancers. View Full-Text
Keywords: osteosarcoma; breast cancer; prostate cancer; cathepsins; metastasis osteosarcoma; breast cancer; prostate cancer; cathepsins; metastasis
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MDPI and ACS Style

Fasanya, H.O.; Siemann, D.W. The Role of Cathepsins in the Growth of Primary and Secondary Neoplasia in the Bone. Osteology 2021, 1, 3-28. https://0-doi-org.brum.beds.ac.uk/10.3390/osteology1010002

AMA Style

Fasanya HO, Siemann DW. The Role of Cathepsins in the Growth of Primary and Secondary Neoplasia in the Bone. Osteology. 2021; 1(1):3-28. https://0-doi-org.brum.beds.ac.uk/10.3390/osteology1010002

Chicago/Turabian Style

Fasanya, Henrietta O.; Siemann, Dietmar W. 2021. "The Role of Cathepsins in the Growth of Primary and Secondary Neoplasia in the Bone" Osteology 1, no. 1: 3-28. https://0-doi-org.brum.beds.ac.uk/10.3390/osteology1010002

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