Next Article in Journal
An Overview of Achilles Tendinopathy Management
Previous Article in Journal
Multi-Level Fibrotomy for Pediatric Patients with Cerebral Palsy: A Cohort Study
Review

Chondrogenic Potential of Dental-Derived Mesenchymal Stromal Cells

1
Department of Orthopaedics, School of Medical Sciences and Research, Sharda University, Greater Noida 201306, India
2
Indian Stem Cell Study Group (ISCSG) Association, Lucknow 226010, India
3
Fellowship in Orthopaedic Rheumatology (FEIORA), Dr. Ram Manohar Lohiya National Law University, Lucknow 226010, India
4
Department of Orthopaedics, JJM Medical College, Davangere 577004, India
5
Department of Biotechnology, School of Engineering and Technology, Sharda University, Greater Noida 201306, India
6
Orthopaedic Research Group, Coimbatore 641001, India
7
Department of Orthopaedics, Government Medical College and Hospital, Dindigul 624001, India
8
Department of Orthopaedics, Prasad Institute of Medical Sciences, Lucknow 226010, India
*
Authors to whom correspondence should be addressed.
Academic Editor: Jan Zabrzyński
Received: 23 August 2021 / Revised: 7 September 2021 / Accepted: 13 September 2021 / Published: 15 September 2021
The field of tissue engineering has revolutionized the world in organ and tissue regeneration. With the robust research among regenerative medicine experts and researchers, the plausibility of regenerating cartilage has come into the limelight. For cartilage tissue engineering, orthopedic surgeons and orthobiologists use the mesenchymal stromal cells (MSCs) of various origins along with the cytokines, growth factors, and scaffolds. The least utilized MSCs are of dental origin, which are the richest sources of stromal and progenitor cells. There is a paradigm shift towards the utilization of dental source MSCs in chondrogenesis and cartilage regeneration. Dental-derived MSCs possess similar phenotypes and genotypes like other sources of MSCs along with specific markers such as dentin matrix acidic phosphoprotein (DMP) -1, dentin sialophosphoprotein (DSPP), alkaline phosphatase (ALP), osteopontin (OPN), bone sialoprotein (BSP), and STRO-1. Concerning chondrogenicity, there is literature with marginal use of dental-derived MSCs. Various studies provide evidence for in-vitro and in-vivo chondrogenesis by dental-derived MSCs. With such evidence, clinical trials must be taken up to support or refute the evidence for regenerating cartilage tissues by dental-derived MSCs. This article highlights the significance of dental-derived MSCs for cartilage tissue regeneration. View Full-Text
Keywords: dental pulp; mesenchymal stromal cell; chondrogenicity dental pulp; mesenchymal stromal cell; chondrogenicity
Show Figures

Figure 1

MDPI and ACS Style

Jeyaraman, N.; Prajwal, G.S.; Jeyaraman, M.; Muthu, S.; Khanna, M. Chondrogenic Potential of Dental-Derived Mesenchymal Stromal Cells. Osteology 2021, 1, 149-174. https://0-doi-org.brum.beds.ac.uk/10.3390/osteology1030016

AMA Style

Jeyaraman N, Prajwal GS, Jeyaraman M, Muthu S, Khanna M. Chondrogenic Potential of Dental-Derived Mesenchymal Stromal Cells. Osteology. 2021; 1(3):149-174. https://0-doi-org.brum.beds.ac.uk/10.3390/osteology1030016

Chicago/Turabian Style

Jeyaraman, Naveen, Gollahalli S. Prajwal, Madhan Jeyaraman, Sathish Muthu, and Manish Khanna. 2021. "Chondrogenic Potential of Dental-Derived Mesenchymal Stromal Cells" Osteology 1, no. 3: 149-174. https://0-doi-org.brum.beds.ac.uk/10.3390/osteology1030016

Find Other Styles

Article Access Map by Country/Region

1
Back to TopTop