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Chondrogenic Potential of Dental-Derived Mesenchymal Stromal Cells

Department of Orthopaedics, School of Medical Sciences and Research, Sharda University, Greater Noida 201306, India
Indian Stem Cell Study Group (ISCSG) Association, Lucknow 226010, India
Fellowship in Orthopaedic Rheumatology (FEIORA), Dr. Ram Manohar Lohiya National Law University, Lucknow 226010, India
Department of Orthopaedics, JJM Medical College, Davangere 577004, India
Department of Biotechnology, School of Engineering and Technology, Sharda University, Greater Noida 201306, India
Orthopaedic Research Group, Coimbatore 641001, India
Department of Orthopaedics, Government Medical College and Hospital, Dindigul 624001, India
Department of Orthopaedics, Prasad Institute of Medical Sciences, Lucknow 226010, India
Authors to whom correspondence should be addressed.
Academic Editor: Jan Zabrzyński
Received: 23 August 2021 / Revised: 7 September 2021 / Accepted: 13 September 2021 / Published: 15 September 2021
The field of tissue engineering has revolutionized the world in organ and tissue regeneration. With the robust research among regenerative medicine experts and researchers, the plausibility of regenerating cartilage has come into the limelight. For cartilage tissue engineering, orthopedic surgeons and orthobiologists use the mesenchymal stromal cells (MSCs) of various origins along with the cytokines, growth factors, and scaffolds. The least utilized MSCs are of dental origin, which are the richest sources of stromal and progenitor cells. There is a paradigm shift towards the utilization of dental source MSCs in chondrogenesis and cartilage regeneration. Dental-derived MSCs possess similar phenotypes and genotypes like other sources of MSCs along with specific markers such as dentin matrix acidic phosphoprotein (DMP) -1, dentin sialophosphoprotein (DSPP), alkaline phosphatase (ALP), osteopontin (OPN), bone sialoprotein (BSP), and STRO-1. Concerning chondrogenicity, there is literature with marginal use of dental-derived MSCs. Various studies provide evidence for in-vitro and in-vivo chondrogenesis by dental-derived MSCs. With such evidence, clinical trials must be taken up to support or refute the evidence for regenerating cartilage tissues by dental-derived MSCs. This article highlights the significance of dental-derived MSCs for cartilage tissue regeneration. View Full-Text
Keywords: dental pulp; mesenchymal stromal cell; chondrogenicity dental pulp; mesenchymal stromal cell; chondrogenicity
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MDPI and ACS Style

Jeyaraman, N.; Prajwal, G.S.; Jeyaraman, M.; Muthu, S.; Khanna, M. Chondrogenic Potential of Dental-Derived Mesenchymal Stromal Cells. Osteology 2021, 1, 149-174.

AMA Style

Jeyaraman N, Prajwal GS, Jeyaraman M, Muthu S, Khanna M. Chondrogenic Potential of Dental-Derived Mesenchymal Stromal Cells. Osteology. 2021; 1(3):149-174.

Chicago/Turabian Style

Jeyaraman, Naveen, Gollahalli S. Prajwal, Madhan Jeyaraman, Sathish Muthu, and Manish Khanna. 2021. "Chondrogenic Potential of Dental-Derived Mesenchymal Stromal Cells" Osteology 1, no. 3: 149-174.

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