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The Acceptability of Faecal Microbiota Transplant for Anterior Resection Syndrome (AFFINITY) Study

1
Health Education and Improvement Wales, Nantgarw CF15 7QQ, UK
2
Cedar Healthcare Technology Research Centre, Cardiff Medicentre, Heath Park, Cardiff CF14 4UJ, UK
3
Department of Colorectal Surgery, University Hopsital of Wales, Heath Park, Cardiff, CF14 4XW, UK
*
Author to whom correspondence should be addressed.
Received: 28 May 2020 / Revised: 15 June 2020 / Accepted: 18 June 2020 / Published: 21 June 2020
Low anterior resection syndrome (LARS) is recognised as disordered bowel function after rectal resection. Temporary ileostomy is associated with LARS and with reduced colonic bacteria. Faecal microbiota transplant (FMT) is the introduction of enteric bacteria from healthy donors into a patient’s gut. We hypothesise that FMT could improve bowel function after ileostomy reversal. We aim to determine whether FMT would be acceptable to patients. Patients who had undergone anterior resection in the previous two years across four sites were sent questionnaires. A group of patients were invited to a focus group to explore their views further. There were 98 eligible patients, of whom 40 responded (41%); 67% were male, median age was 67 (range 31–83) years, and 11 still had a stoma. Of those who had their stoma reversed, 52% had major LARS symptoms. Sixty-five percent thought the concept of FMT sounded effective and 70% were willing to try it. A healthy anonymous donor and FMT via enema were the most acceptable options to the respondents. Seven patients attended the focus group; 2 female, 5 male, mean age 66 (range 45–75) years. All patients thought FMT was acceptable but the word “faecal” made it less acceptable. All participants would consider entering a trial with FMT as a treatment option. The main concerns were safety and efficacy. The majority of patients who responded thought FMT was acceptable and were willing to try it as a potential treatment option. View Full-Text
Keywords: faecal microbiota transplant; anterior resection; ileostomy; LARS faecal microbiota transplant; anterior resection; ileostomy; LARS
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MDPI and ACS Style

Powell-Chandler, A.; Withers, K.L.; Carolan-Rees, G.; Cornish, J.A. The Acceptability of Faecal Microbiota Transplant for Anterior Resection Syndrome (AFFINITY) Study. Surgeries 2020, 1, 10-20. https://0-doi-org.brum.beds.ac.uk/10.3390/surgeries1010003

AMA Style

Powell-Chandler A, Withers KL, Carolan-Rees G, Cornish JA. The Acceptability of Faecal Microbiota Transplant for Anterior Resection Syndrome (AFFINITY) Study. Surgeries. 2020; 1(1):10-20. https://0-doi-org.brum.beds.ac.uk/10.3390/surgeries1010003

Chicago/Turabian Style

Powell-Chandler, Anna, Kathleen L. Withers, Grace Carolan-Rees, and Julie A. Cornish 2020. "The Acceptability of Faecal Microbiota Transplant for Anterior Resection Syndrome (AFFINITY) Study" Surgeries 1, no. 1: 10-20. https://0-doi-org.brum.beds.ac.uk/10.3390/surgeries1010003

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