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Chiral Dualism as a Unifying Principle in Molecular Biophysics

Faculty of Physics, Lomonosov Moscow State University, Leninskie Gory 1–2, 119234 Moscow, Russia
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Received: 30 December 2020 / Revised: 28 January 2021 / Accepted: 1 February 2021 / Published: 8 February 2021
The origin and potential role of chiral asymmetry remain one of the most exciting issues in biology. In this paper we review the chirality of biological macromolecules, starting at the level of single molecules and continuing to the level of supramolecular assemblies. We discuss the physical and chemical consequences of the presence of chirality and their role in the self-organization and formation of structural hierarchies in cells. Homochirality may serve as an essential factor that invokes mechanisms required to control the formation of discrete structural hierarchies in macromolecules and macromolecular assemblies. Symmetry is of fundamental importance not only for all molecular biology as a systemic factor of its organization but also for pharmacology, as well as a systemic factor of drug stereospecificity. View Full-Text
Keywords: chirality; proteins; nucleic acids; hierarchy of structures; chiral drugs chirality; proteins; nucleic acids; hierarchy of structures; chiral drugs
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MDPI and ACS Style

Malyshko, E.V.; Semenova, E.V.; Bagrova, O.E.; Murtazina, A.R.; Tverdislov, V.A. Chiral Dualism as a Unifying Principle in Molecular Biophysics. Biophysica 2021, 1, 22-37. https://0-doi-org.brum.beds.ac.uk/10.3390/biophysica1010003

AMA Style

Malyshko EV, Semenova EV, Bagrova OE, Murtazina AR, Tverdislov VA. Chiral Dualism as a Unifying Principle in Molecular Biophysics. Biophysica. 2021; 1(1):22-37. https://0-doi-org.brum.beds.ac.uk/10.3390/biophysica1010003

Chicago/Turabian Style

Malyshko, Ekaterina V., Ekaterina V. Semenova, Olga E. Bagrova, Alina R. Murtazina, and Vsevolod A. Tverdislov 2021. "Chiral Dualism as a Unifying Principle in Molecular Biophysics" Biophysica 1, no. 1: 22-37. https://0-doi-org.brum.beds.ac.uk/10.3390/biophysica1010003

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