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Commentary

Therapeutic Strategies for Diabetic Kidney Disease

Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo 105-8461, Japan
Received: 20 January 2021 / Revised: 2 March 2021 / Accepted: 6 March 2021 / Published: 12 March 2021
Diabetic kidney disease (DKD) is a global epidemic leading to end-stage renal disease (ESRD) and susceptibility to cardiovascular disease, with few therapeutic interventions. A hallmark of DKD is the activation of the renin-angiotensin-aldosterone system and hemodynamic changes in glomerulus. Although intensive therapy with agents that targets those abnormalities lowers the risk of DKD progression, it does not completely abolish the risk of ESRD and cardiovascular events. Recent studies have illustrated the importance of renal inflammation, oxidative stress, and activated Rho-associated protein kinase (ROCK) signaling as essential pathogenesis for the development of DKD. In this commentary, these topics will be discussed. View Full-Text
Keywords: diabetes; diabetic kidney disease; mineralocorticoid receptor; inflammation; sodium–glucose cotransporter 2 (sglt2) inhibitors; chronic kidney disease diabetes; diabetic kidney disease; mineralocorticoid receptor; inflammation; sodium–glucose cotransporter 2 (sglt2) inhibitors; chronic kidney disease
MDPI and ACS Style

Matoba, K. Therapeutic Strategies for Diabetic Kidney Disease. Diabetology 2021, 2, 31-35. https://0-doi-org.brum.beds.ac.uk/10.3390/diabetology2010003

AMA Style

Matoba K. Therapeutic Strategies for Diabetic Kidney Disease. Diabetology. 2021; 2(1):31-35. https://0-doi-org.brum.beds.ac.uk/10.3390/diabetology2010003

Chicago/Turabian Style

Matoba, Keiichiro. 2021. "Therapeutic Strategies for Diabetic Kidney Disease" Diabetology 2, no. 1: 31-35. https://0-doi-org.brum.beds.ac.uk/10.3390/diabetology2010003

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