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Proceeding Paper

Protective Effect of Cyclolepis genistoides Aqueous Extract against Cellular Oxidative Stress

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Instituto de Investigaciones Bioquímicas de Bahía Blanca (INIBIBB)—Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Camino La Carrindanga km 7, Bahía Blanca 8000, Argentina
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Departamento de Química—Universidad Nacional del Sur (UNS), Avenida Alem 1253, Bahía Blanca 8000, Argentina
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Departamento de Biología, Bioquímica y Farmacia—(UNS), San Juan 670, Bahía Blanca 8000, Argentina
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Instituto de Química del Sur (INQUISUR-CONICET) Avenida Alem 1253, Bahía Blanca 8000, Argentina
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Author to whom correspondence should be addressed.
In Proceedings of the 24th International Electronic Conference on Synthetic Organic Chemistry, 15 November–15 December 2020; Available online: https://ecsoc-24.sciforum.net/.
Academic Editors: Julio A. Seijas and M. Pilar Vázquez-Tato
Published: 14 November 2020
The development of neuroprotective agents constitutes one of the most promising strategies to treat neurodegenerative disorders, such as Parkinson’s disease (PD). Oxidative stress (OS) is a major contributor to the death of dopaminergic neurons in PD. In the present work, we investigated the effect of aqueous extracts of three Argentinian medicinal plants, Agalinis genistifolia (Cham. & Schltdl.) D’Arcy, Cyclolepis genistoides Gillies ex D. Don and Margyricarpus pinnatus (Lam.) Kuntze, on cellular models of metal-induced OS. These species have been traditionally used to treat PD-related symptoms, such as paralysis for A. genistifolia and inflammation for C. genistoides and M. pinnatus. To evaluate the potential neuroprotective activity of the aqueous extracts, we used the human neuroblastoma cell line IMR-32 exposed to ferric ammonium citrate (FAC) as an OS inducer. Whereas cells exposed to FAC exhibited increased levels of reactive oxygen species (ROS) after the treatment with A. genistifolia and M. pinnatus (50 µg/mL extract), the exposure to C. genistoides extract at 20 µg/mL showed a reduction in ROS levels. In line with this finding, we found that C. genistoides treatment decreased lipid peroxidation under the same experimental conditions (20 µg/mL). Furthermore, the induction of ROS production by manganese in IMR-32 cells and by FAC in N27 rat dopaminergic cells was attenuated by the exposure to C. genistoides extract. Our results suggest that the aqueous extract of C. genistoides has potential as a source of neuroprotective agents that can target OS, a hallmark of neuronal death in PD.
Keywords: neuroprotective agents; oxidative stress; medicinal plants neuroprotective agents; oxidative stress; medicinal plants
MDPI and ACS Style

Alza, N.; Juncos, O.B.; Murray, A.; Salvador, G. Protective Effect of Cyclolepis genistoides Aqueous Extract against Cellular Oxidative Stress. Chem. Proc. 2021, 3, 104. https://0-doi-org.brum.beds.ac.uk/10.3390/ecsoc-24-08344

AMA Style

Alza N, Juncos OB, Murray A, Salvador G. Protective Effect of Cyclolepis genistoides Aqueous Extract against Cellular Oxidative Stress. Chemistry Proceedings. 2021; 3(1):104. https://0-doi-org.brum.beds.ac.uk/10.3390/ecsoc-24-08344

Chicago/Turabian Style

Alza, Natalia, Oriana Benzi Juncos, Ana Murray, and Gabriela Salvador. 2021. "Protective Effect of Cyclolepis genistoides Aqueous Extract against Cellular Oxidative Stress" Chemistry Proceedings 3, no. 1: 104. https://0-doi-org.brum.beds.ac.uk/10.3390/ecsoc-24-08344

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