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Microwave-Assisted Multicomponent Syntheses of Heterocyclic Phosphonates

Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1521 Budapest, Hungary
Faculty of Chemistry and Chemical Technology, University of Ljubljana, SI-1000 Ljubljana, Slovenia
Author to whom correspondence should be addressed.
Presented at the 24th International Electronic Conference on Synthetic Organic Chemistry, 15 November–15 December 2020; Available online:
Published: 25 November 2020
Organophosphorus compounds play an important role in the medicinal- or agricultural industry, and in the human body as well. Over the last years, heterocyclic phosphonates have received growing interest due to their potential biological activity. An efficient tool for the preparation of such derivatives is their synthesis via multicomponent reactions. These transformations possess several criteria of an “ideal synthesis”, such as high atom economy, fast and simple accomplishment, energy efficiency, and environmentally friendliness. A number of heterocyclic phosphonates were prepared by us utilizing multicomponent syntheses. In this proceeding, the synthesis of the diethyl (2-amino-3-cyano-4H-chromen-4-yl)phosphonate by the condensation of salicylaldehyde, malononitrile and diethyl phosphite is briefly introduced. The reaction was optimized in respect of the catalyst type, the catalyst amount, the reaction time, and the temperature.
Keywords: (4H-chromen-4-yl)phosphonate; microwave; three-component reaction; multicomponent synthesis (4H-chromen-4-yl)phosphonate; microwave; three-component reaction; multicomponent synthesis
MDPI and ACS Style

Bálint, E.; Popovics-Tóth, N.; Tajti, Á.; Rávai, B.; Szabó, K.E.; Perdih, F. Microwave-Assisted Multicomponent Syntheses of Heterocyclic Phosphonates. Chem. Proc. 2021, 3, 108.

AMA Style

Bálint E, Popovics-Tóth N, Tajti Á, Rávai B, Szabó KE, Perdih F. Microwave-Assisted Multicomponent Syntheses of Heterocyclic Phosphonates. Chemistry Proceedings. 2021; 3(1):108.

Chicago/Turabian Style

Bálint, Erika, Nóra Popovics-Tóth, Ádám Tajti, Bettina Rávai, Kármen E. Szabó, and Franc Perdih. 2021. "Microwave-Assisted Multicomponent Syntheses of Heterocyclic Phosphonates" Chemistry Proceedings 3, no. 1: 108.

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