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Proceedings

Study of ADMET Descriptors of Novel Chlorinated N-Arylcinnamamides

1
Department of Analytical Chemistry, Faculty of Natural Sciences, Comenius University, Ilkovicova 6, 842 15 Bratislava, Slovakia
2
Regional Centre of Advanced Technologies and Materials, Faculty of Science, Palacky University, Slechtitelu 27, 783 71 Olomouc, Czech Republic
*
Authors to whom correspondence should be addressed.
Presented at the 24th International Electronic Conference on Synthetic Organic Chemistry, 15 November–15 December 2020; Available online: https://ecsoc-24.sciforum.net/.
Published: 14 December 2020
(2E)-3-(3,4-Dichlorophenyl)-N-arylprop-2-enanilides were designed as potential bioactive agents. Six compounds were mono- and di-chlorinated also on the anilide ring. Since the biological activities of molecules are influenced by lipophilicity, the hydro-lipophilic characteristics of these compounds were experimentally studied. In addition, the overall ADMET (absorption, distribution, metabolism, excretion, toxicity) profiles of these molecules were studied to establish whether they comply with the Lipinski’s rule of five and thus meet the “druglikeness” requirement. All the compounds were analyzed using the reversed-phase high performance liquid chromatography method. The procedure was carried out under isocratic conditions and a C18 stationary reversed-phase column. The structure–lipophilicity relationships of the investigated compounds are discussed.
Keywords: N-arylcinnamamides; synthesis; lipophilicity; ADMET; structure-lipophilicity relationships N-arylcinnamamides; synthesis; lipophilicity; ADMET; structure-lipophilicity relationships
MDPI and ACS Style

Pindjakova, D.; Strharsky, T.; Kos, J.; Vrablova, L.; Hutta, M.; Jampilek, J. Study of ADMET Descriptors of Novel Chlorinated N-Arylcinnamamides. Chem. Proc. 2021, 3, 121. https://0-doi-org.brum.beds.ac.uk/10.3390/ecsoc-24-08298

AMA Style

Pindjakova D, Strharsky T, Kos J, Vrablova L, Hutta M, Jampilek J. Study of ADMET Descriptors of Novel Chlorinated N-Arylcinnamamides. Chemistry Proceedings. 2021; 3(1):121. https://0-doi-org.brum.beds.ac.uk/10.3390/ecsoc-24-08298

Chicago/Turabian Style

Pindjakova, Dominika, Tomas Strharsky, Jiri Kos, Lucia Vrablova, Milan Hutta, and Josef Jampilek. 2021. "Study of ADMET Descriptors of Novel Chlorinated N-Arylcinnamamides" Chemistry Proceedings 3, no. 1: 121. https://0-doi-org.brum.beds.ac.uk/10.3390/ecsoc-24-08298

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