Next Article in Journal
Chemical Fingerprinting and Antimicrobial Evaluation of the Methanolic Extract of the Leaves of the Endemic Cuban Plant Coccoloba cowellii
Previous Article in Journal
Polyphenols from Thelesperma megapotamicum and Their Antioxidant and Neuroprotective Activities
Proceedings

Xanthine Oxidase Inhibition by Aqueous Extract of Limonium brasiliense (Plumbaginaceae)

1
Departamento de Química, INQUISUR, UNS, B8000CPB Bahía Blanca, Argentina
2
Laboratorio de Parasitología, IIAA, USC, E-15782 Santiago de Compostela, Spain
*
Author to whom correspondence should be addressed.
Presented at the 24th International Electronic Conference on Synthetic Organic Chemistry, 15 November–15 December 2020; Available online: https://ecsoc-24.sciforum.net/.
Published: 14 December 2020
Limonium brasiliense (Boiss.) Kuntze (Plumbaginaceae) is a medicinal plant that is popularly used in the folk medicine. In this study, we examined xanthine oxidase (XO) inhibitory activity of the aqueous fraction of Limonium brasiliense extract and its polar bioactive constituents using the enzymatic hypoxanthine (HX)–XO system in vitro. Seven active compounds isolated from the aqueous extract proved to be strong XO inhibitors. Prodelphinidin B1-3,3′-digallate (1) showed the most potent inhibitory activity with an IC50 value of 6.61 µM, comparable to allopurinol. This study provides basis for the potential use of the aqueous fraction of L. brasiliense against hyperuricemia, displaying potent XO inhibitory activity with an IC50 value of 48.3 µg/mL. This inhibitory effect is compatible with the presence of (1) in this extract.
Keywords: xanthine oxidase; inhibition; Limonium brasiliense; prodelphinidin B1-3,3′-digallate xanthine oxidase; inhibition; Limonium brasiliense; prodelphinidin B1-3,3′-digallate
MDPI and ACS Style

Rodriguez, S.A.A.; Murray, A.P.P.; Leiro, J.M. Xanthine Oxidase Inhibition by Aqueous Extract of Limonium brasiliense (Plumbaginaceae). Chem. Proc. 2021, 3, 123. https://0-doi-org.brum.beds.ac.uk/10.3390/ecsoc-24-08410

AMA Style

Rodriguez SAA, Murray APP, Leiro JM. Xanthine Oxidase Inhibition by Aqueous Extract of Limonium brasiliense (Plumbaginaceae). Chemistry Proceedings. 2021; 3(1):123. https://0-doi-org.brum.beds.ac.uk/10.3390/ecsoc-24-08410

Chicago/Turabian Style

Rodriguez, Silvana Andrea A., Ana Paula P. Murray, and José Manuel Leiro. 2021. "Xanthine Oxidase Inhibition by Aqueous Extract of Limonium brasiliense (Plumbaginaceae)" Chemistry Proceedings 3, no. 1: 123. https://0-doi-org.brum.beds.ac.uk/10.3390/ecsoc-24-08410

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop