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Proceedings

Synthesis of Amidines and Its Application to Pyrimidouracil Synthesis

Department of Chemistry, Maharaja Bir Bikram College, Agartala, Tripura 799004, India
Presented at the 24th International Electronic Conference on Synthetic Organic Chemistry, 15 November–15 December 2020; Available online: https://ecsoc-24.sciforum.net/.
Published: 20 November 2020
An efficient and sustainable copper-catalyzed protocol has been developed for the preparation of amidines via nucleophilic addition of amines into nitriles. The reaction proceeded smoothly at 100 °C in the presence of CuCl, Cs2CO3, and 2,2/-bipyridine under oxygen (O2) atmosphere in 2,2,2-trifluoroethanol (TFE) solvent. Moreover, a straightforward synthetic method for the synthesis of substituted pyrimidouracils via PhI(OAc)2-mediated oxidative coupling of N-uracil amidines and methylarenes has been developed. The starting materials N-uracil amidines were synthesized from 6-chlorouracil and amidines via nucleophilic substitution reactions.
Keywords: amidine; transition metal; C–H activation; oxidative insertion; pyrimidouracils amidine; transition metal; C–H activation; oxidative insertion; pyrimidouracils
MDPI and ACS Style

Debnath, P. Synthesis of Amidines and Its Application to Pyrimidouracil Synthesis. Chem. Proc. 2021, 3, 132. https://0-doi-org.brum.beds.ac.uk/10.3390/ecsoc-24-08503

AMA Style

Debnath P. Synthesis of Amidines and Its Application to Pyrimidouracil Synthesis. Chemistry Proceedings. 2021; 3(1):132. https://0-doi-org.brum.beds.ac.uk/10.3390/ecsoc-24-08503

Chicago/Turabian Style

Debnath, Pradip. 2021. "Synthesis of Amidines and Its Application to Pyrimidouracil Synthesis" Chemistry Proceedings 3, no. 1: 132. https://0-doi-org.brum.beds.ac.uk/10.3390/ecsoc-24-08503

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