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Preliminary Evaluation of Pullulan Nanoparticles Loaded with Valsartan

National Institute for Chemical-Pharmaceutical Research & Development—ICCF Bucharest, 112, Vitan Avenue, 031299 Bucharest, Romania
Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 1-7 Gheorghe POLIZU St., 011061 Bucharest, Romania
Faculty of Pharmacy, University of Medicine and Pharmacy Grigore T.Popa, 16 Universitatii, 700115 Iasi, Romania
Author to whom correspondence should be addressed.
Presented at the 24th International Electronic Conference on Synthetic Organic Chemistry, 15 November–15 December 2020; Available online:
Published: 14 November 2020
The objective of this paper is to develop polymeric nanoparticles loaded with a cardiovascular drug (an angiotensin II receptor blocker, valsartan). Polymeric nanoparticles were prepared via the nanoprecipitation method using pullulan acetate as biodegradable polymeric matrix and Pluronic F127 as a stabilizer. Pullulan acetate was obtained through the chemical modification of pullulan (produced through a fermentation process using the Aureobasidium pullulans strain) with dimethylformamide, pyridine and acetic anhydride. The obtained nanoparticles were characterized in terms of entrapment efficiency, size, and polydispersity index using spectrophotometric and dynamic light scattering techniques. The valsartan-loaded nanoparticles showed a good entrapment efficiency of valsartan, nanometric sizes (lower than 200 nm), and a narrow dispersity (polydispersity index below 0.2). This research revealed that pullulan and pullulan derivatives show great potential for the production of nanoparticles, with potential application in the delivery of cardiovascular agents.
Keywords: pullulan; nanoparticles; valsartan; cardiovascular disease pullulan; nanoparticles; valsartan; cardiovascular disease
MDPI and ACS Style

Pavaloiu, R.-D.; Sha’at, F.; Hlevca, C.; Sha’at, M.; Sevcenco, C.; Petrescu, M.; Eremia, M.; Moscovici, M. Preliminary Evaluation of Pullulan Nanoparticles Loaded with Valsartan. Chem. Proc. 2021, 3, 139.

AMA Style

Pavaloiu R-D, Sha’at F, Hlevca C, Sha’at M, Sevcenco C, Petrescu M, Eremia M, Moscovici M. Preliminary Evaluation of Pullulan Nanoparticles Loaded with Valsartan. Chemistry Proceedings. 2021; 3(1):139.

Chicago/Turabian Style

Pavaloiu, Ramona-Daniela, Fawzia Sha’at, Cristina Hlevca, Mousa Sha’at, Claudia Sevcenco, Maria Petrescu, Mihaela Eremia, and Mișu Moscovici. 2021. "Preliminary Evaluation of Pullulan Nanoparticles Loaded with Valsartan" Chemistry Proceedings 3, no. 1: 139.

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