Immuno, Volume 1, Issue 1 (March 2021) – 3 articles

  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list.
  • You may sign up for e-mail alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Readerexternal link to open them.
Order results
Result details
Select all
Export citation of selected articles as:
Open AccessReview
Potential Beneficial Effects of Vitamin K in SARS-CoV-2 Induced Vascular Disease?
Immuno 2021, 1(1), 17-29; https://0-doi-org.brum.beds.ac.uk/10.3390/immuno1010003 - 17 Feb 2021
Viewed by 242
Abstract
Prevalent coagulopathy and thromboembolism are observed in severe COVID-19 patients with 40% of COVID-19 mortality being associated with cardiovascular complications. Abnormal coagulation parameters are related to poor prognosis in COVID-19 patients. Victims also displayed presence of extensive thrombosis in infected lungs. Vitamin K [...] Read more.
Prevalent coagulopathy and thromboembolism are observed in severe COVID-19 patients with 40% of COVID-19 mortality being associated with cardiovascular complications. Abnormal coagulation parameters are related to poor prognosis in COVID-19 patients. Victims also displayed presence of extensive thrombosis in infected lungs. Vitamin K is well-known to play an essential role in the coagulation system. Latest study revealed an existing correlation between vitamin K deficiency and COVID-19 severity, highlighting a role of vitamin K, probably via coagulation modulation. In agreement, other recent studies also indicated that anti-coagulant treatments can reduce mortality in severe cases. Altogether, potential mechanisms linking COVID-19 with coagulopathy in which vitamin K may exert its modulating role in coagulation related with disease pathogenesis are established. In this review, we discuss the recent evidence supporting COVID-19 as a vascular disease and explore the potential benefits of using vitamin K against COVID-19 to improve disease outcomes. Full article
Show Figures

Figure 1

Open AccessEditorial
Immuno—A New Multidisciplinary Open Access Journal for Immunological Science and Medicine
Immuno 2021, 1(1), 15-16; https://0-doi-org.brum.beds.ac.uk/10.3390/immuno1010002 - 19 Jan 2021
Viewed by 344
Abstract
Welcome to Immuno [...] Full article
Show Figures

Figure 1

Open AccessReview
Reprogramming of Central Carbon Metabolism in Myeloid Cells upon Innate Immune Receptor Stimulation
Immuno 2021, 1(1), 1-14; https://0-doi-org.brum.beds.ac.uk/10.3390/immuno1010001 - 11 Jan 2021
Viewed by 415
Abstract
Immunometabolism is a relatively new field of research that aims at understanding interconnections between the immune system and cellular metabolism. This is now well-documented for innate immune cells of the myeloid lineage such as macrophages and myeloid dendritic cells (DCs) when they engage [...] Read more.
Immunometabolism is a relatively new field of research that aims at understanding interconnections between the immune system and cellular metabolism. This is now well-documented for innate immune cells of the myeloid lineage such as macrophages and myeloid dendritic cells (DCs) when they engage their differentiation or activation programs. Several studies have shown that stimulation of DCs or macrophages by the binding of pathogen-associated molecular patterns (PAMPs) to pattern recognition receptors (PRRs) leads to increased glycolytic activity and rewiring of central carbon metabolism. These metabolic modulations are essential to support and settle immunological functions by providing energy and immunoregulatory metabolites. As the understanding of molecular mechanisms progressed, significant differences between cell types and species have also been discovered. Pathways leading to the regulation of central carbon metabolism in macrophages and DCs by PRR signaling and consequences on cellular functions are reviewed here. Full article
Show Figures

Figure 1

Back to TopTop