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Article

Polyethylene Oxide Hydrogels Crosslinked by Peroxide for the Controlled Release of Proteins

1
Theoretical and Physical Chemistry Institute, National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, 11635 Athens, Greece
2
Department of Chemical Engineering, University of Patras, 26504 Patras, Greece
3
Jülich Centre for Neutron Science JCNS Forschungszentrum Jülich GmbH, Outstation at Heinz Maier-Leibnitz Zentrum (MLZ), Lichtenbergstraße 1, 85747 Garching, Germany
*
Authors to whom correspondence should be addressed.
Received: 2 December 2020 / Revised: 18 December 2020 / Accepted: 18 December 2020 / Published: 22 December 2020
Crosslinking of polyethylene oxide (PEO) using a peroxide in the melt is employed to synthesize soft hydrogels with the ability of controlled release of proteins. The viscoelastic properties of the swollen networks confirm the elastic nature of the synthesized material and they are in agreement with swelling characteristics. The hydrogels have mesh sizes at the nm scale as it is estimated by swelling measurements and measured by small angle neutron scattering (SANS). Diffusion of bovine serum albumin (BSA) and lysozyme (LYZ) out of the hydrogels is restricted by the presence of the network. The diffusion coefficient in the hydrogels is lower for BSA in comparison to LYZ, while in both cases it drops as the mesh size of the network becomes smaller. This study introduces the use of peroxide-crosslinked PEO networks in the investigation of protein transport within hydrogels, the development of hydrogel-based protein delivery patches and polymeric constructs. View Full-Text
Keywords: small angle neutron scattering; diffusion; mesh-size; network; rheology small angle neutron scattering; diffusion; mesh-size; network; rheology
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MDPI and ACS Style

Papagiannopoulos, A.; Vlassi, E.; Pispas, S.; Tsitsilianis, C.; Radulescu, A. Polyethylene Oxide Hydrogels Crosslinked by Peroxide for the Controlled Release of Proteins. Macromol 2021, 1, 37-48. https://0-doi-org.brum.beds.ac.uk/10.3390/macromol1010004

AMA Style

Papagiannopoulos A, Vlassi E, Pispas S, Tsitsilianis C, Radulescu A. Polyethylene Oxide Hydrogels Crosslinked by Peroxide for the Controlled Release of Proteins. Macromol. 2021; 1(1):37-48. https://0-doi-org.brum.beds.ac.uk/10.3390/macromol1010004

Chicago/Turabian Style

Papagiannopoulos, Aristeidis, Eleni Vlassi, Stergios Pispas, Constantinos Tsitsilianis, and Aurel Radulescu. 2021. "Polyethylene Oxide Hydrogels Crosslinked by Peroxide for the Controlled Release of Proteins" Macromol 1, no. 1: 37-48. https://0-doi-org.brum.beds.ac.uk/10.3390/macromol1010004

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