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Effect of the Croton rhamnifolioides Essential Oil and the Inclusion Complex (OEFC/β-CD) in Antinociceptive Animal Models

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Laboratory of Pharmacology and Preclinical Bioactive Product Toxicology, Graduate Program in Pharmaceutical Sciences, Federal University of Pernambuco, Av. Prof. Moraes Rego, 1235—Cidade Universitária, Recife 50670-901, Brazil
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Laboratory of Pharmacology and Molecular Chemistry, Department of Biological Chemistry, Regional University of Cariri, Rua Coronel Antônio Luis 1161, Pimenta, Crato 63105-000, Brazil
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Laboratory of Neuroscience and Pharmacological Assays, Department of Physiology, Federal University of Sergipe, Avenue Marechal Rondon, S/N, São Cristóvão 49100-000, Brazil
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Laboratory of Pharmaceutical Testing and Toxicity, Department of Pharmacy, Federal University of Sergipe, Avenida Marechal Rondon, S/N, São Cristóvão 49100-000, Brazil
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Laboratory of Microbiology and Molecular Biology, Department of Biological Chemistry, Regional University of Cariri, Rua Coronel Antônio Luis 1161, Pimenta, Crato 63105-000, Brazil
*
Author to whom correspondence should be addressed.
Academic Editors: Aristeidis Papagiannopoulos and Alejandro Baeza
Received: 20 January 2021 / Revised: 9 March 2021 / Accepted: 16 March 2021 / Published: 6 April 2021
(This article belongs to the Special Issue Polymers in Nanocarrier Systems)
This study aims to evaluate the antinociceptive effect of the C. rhamnifolioides leaf essential oil (OEFC) and the β-cyclodextrin inclusion complex (COEFC) and investigate the pain signaling pathways involved in the antinociceptive response. The effects of the OEFC and COEFC on the central nervous system (CNS) were determined by open field and rota-rod assays, and the antinociceptive effect was evaluated via the acetic acid-induced abdominal contortions, formalin, and hot plate models. Swiss (Mus musculus) male mice (20–30 g) were used in both trials. The OEFC (200 mg/kg/v.o-orally) and COEFC (83.5 mg/kg/v.o.) did not present alterations in the CNS. The OEFC (25, 50, 100, and 200 mg/kg/vo.) and COEFC (8.35, 41.75, and 83.5 mg/kg/v.o.) demonstrated antinociceptive effects in the abdominal contortions, formalin, and hot plate tests. The OEFC (25 mg/kg/v.o.) and COEFC (8.35 mg/kg/v.o.) doses showed that the antinociceptive effect involves the activation of the opioid, cholinergic, and vanilloid systems, as well as the L-arginine/NO and α-2 adrenergic receptor pathways. The antinociceptive potential the OEFC and COEFC demonstrate possible alternatives for the therapy of pain. However, the COEFC presented more significant effects at lower doses than the isolated OEFC, where this action may be justified by the properties and advantages of the complexation. View Full-Text
Keywords: Croton rhamnifolioides; nociception; cyclodextrins; complexation; essential oil Croton rhamnifolioides; nociception; cyclodextrins; complexation; essential oil
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MDPI and ACS Style

Oliveira Brito Pereira Bezerra Martins, A.; Correia de Oliveira, M.R.; Alcântara, I.S.; Rodrigues, L.B.; Cesário, F.R.A.S.; da Silva, M.S.A.; Castro, F.F.e.; Nascimento, E.P.d.; Albuquerque, T.R.d.; Quintans Júnior, L.J.; Araújo, A.A.d.S.; Coutinho, H.D.M.; Menezes, I.R.A.d.; Wanderley, A.G. Effect of the Croton rhamnifolioides Essential Oil and the Inclusion Complex (OEFC/β-CD) in Antinociceptive Animal Models. Macromol 2021, 1, 94-111. https://0-doi-org.brum.beds.ac.uk/10.3390/macromol1020008

AMA Style

Oliveira Brito Pereira Bezerra Martins A, Correia de Oliveira MR, Alcântara IS, Rodrigues LB, Cesário FRAS, da Silva MSA, Castro FFe, Nascimento EPd, Albuquerque TRd, Quintans Júnior LJ, Araújo AAdS, Coutinho HDM, Menezes IRAd, Wanderley AG. Effect of the Croton rhamnifolioides Essential Oil and the Inclusion Complex (OEFC/β-CD) in Antinociceptive Animal Models. Macromol. 2021; 1(2):94-111. https://0-doi-org.brum.beds.ac.uk/10.3390/macromol1020008

Chicago/Turabian Style

Oliveira Brito Pereira Bezerra Martins, Anita, Maria R. Correia de Oliveira, Isabel S. Alcântara, Lindaiane B. Rodrigues, Francisco R.A.S. Cesário, Maria S.A. da Silva, Fyama F.e. Castro, Emmily P.d. Nascimento, Thaís R.d. Albuquerque, Lucindo J. Quintans Júnior, Adriano A.d.S. Araújo, Henrique D.M. Coutinho, Irwin R.A.d. Menezes, and Almir G. Wanderley 2021. "Effect of the Croton rhamnifolioides Essential Oil and the Inclusion Complex (OEFC/β-CD) in Antinociceptive Animal Models" Macromol 1, no. 2: 94-111. https://0-doi-org.brum.beds.ac.uk/10.3390/macromol1020008

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