Next Article in Journal
Individualised Risk Assessments for Recurrent Venous Thromboembolism: New Frontiers in the Era of Direct Oral Anticoagulants
Next Article in Special Issue
Human Bone Marrow Mesenchymal Stromal Cell-Derived CXCL12, IL-6 and GDF-15 and Their Capacity to Support IgG-Secreting Cells in Culture Are Divergently Affected by Doxorubicin
Previous Article in Journal
Why Immunotherapy Fails in Multiple Myeloma
Review

Impaired Hematopoiesis after Allogeneic Hematopoietic Stem Cell Transplantation: Its Pathogenesis and Potential Treatments

Department of Hematology, Sapporo Hokuyu Hospital, Sapporo 003-0006, Japan
Academic Editor: Michèle Sabbah
Received: 30 November 2020 / Revised: 24 December 2020 / Accepted: 29 December 2020 / Published: 2 January 2021
(This article belongs to the Special Issue Stem Cells and Therapy: A Themed Honorary Issue to Prof. Luc Douay)
Impaired hematopoiesis is a serious complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Bone marrow aplasia and peripheral cytopenias arise from primary and secondary graft failure or primary and secondary poor graft function. Chimerism analysis is useful to discriminate these conditions. By determining the pathogenesis of impaired hematopoiesis, a timely and appropriate treatment can be performed. Hematopoietic system principally consists of hematopoietic stem cells and bone marrow microenvironment termed niches. Abnormality in hematopoietic stem and progenitor cells and/or abnormality in the relevant niches give rise to hematological diseases. Allo-HSCT is intended to cure each hematological disease, replacing abnormal hematopoietic stem cells and bone marrow niches with hematopoietic stem cells and bone marrow niches derived from normal donors. Therefore, treatment for graft failure and poor graft function after allo-HSCT is required to proceed based on determining the pathogenesis of impaired hematopoiesis. Recent progress in this area suggests promising treatment manipulations for graft failure and poor graft function. View Full-Text
Keywords: allogeneic hematopoietic stem cell transplantation; impaired hematopoiesis; graft failure; poor graft function; graft-versus-host disease; hematopoietic stem cells; bone marrow niches allogeneic hematopoietic stem cell transplantation; impaired hematopoiesis; graft failure; poor graft function; graft-versus-host disease; hematopoietic stem cells; bone marrow niches
MDPI and ACS Style

Imamura, M. Impaired Hematopoiesis after Allogeneic Hematopoietic Stem Cell Transplantation: Its Pathogenesis and Potential Treatments. Hemato 2021, 2, 43-63. https://0-doi-org.brum.beds.ac.uk/10.3390/hemato2010002

AMA Style

Imamura M. Impaired Hematopoiesis after Allogeneic Hematopoietic Stem Cell Transplantation: Its Pathogenesis and Potential Treatments. Hemato. 2021; 2(1):43-63. https://0-doi-org.brum.beds.ac.uk/10.3390/hemato2010002

Chicago/Turabian Style

Imamura, Masahiro. 2021. "Impaired Hematopoiesis after Allogeneic Hematopoietic Stem Cell Transplantation: Its Pathogenesis and Potential Treatments" Hemato 2, no. 1: 43-63. https://0-doi-org.brum.beds.ac.uk/10.3390/hemato2010002

Find Other Styles

Article Access Map by Country/Region

1
Back to TopTop