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MRI versus CT and PET/CT in the Preoperative Assessment of Hodgkin and Non-Hodgkin Lymphomas

1
Department of Radiological Sciences, Oncology and Pathology, Sapienza University of Rome, Policlinico Umberto I Hospital, 00161 Rome, Italy
2
Department of Radiological Sciences, Ospedale G.B. Grassi, Ostia Lido (RM), 00122 Roma, Italy
3
Nuclear Medicine Unit, Department of Medical-Surgical Sciences and Translational Medicine, Sapienza University of Rome, S.Andrea Hospital, 00189 Rome, Italy
4
Division of Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Policlinico Umberto I Hospital, 00161 Rome, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Andor W. J. M. Glaudemans
Received: 15 July 2021 / Revised: 23 September 2021 / Accepted: 24 September 2021 / Published: 1 October 2021
(This article belongs to the Section Radiolabeled Blood Elements and Other Imaging Modalities)
(1) Background: The purpose of this study is to retrospectively compare CT, MRI, and PET/CT in detecting lymphadenopathies and extra-nodal lesions in lymphoma and in disease staging. (2) Methods: Inclusion criteria were the availability of TB (Total Body) CT and/or PET/CT performed before treatment; MRI performed no later than 2 weeks after TBCT; histological confirmation of lymphoma; clinical-diagnostic follow-up. Using these criteria, we included 64/353 patients with TBCT and MRI performed at our hospital; 20/64 had PET/CT performed in other hospitals. Histology and follow-up were gold standard. (3) Results: The sensitivity, specificity, and accuracy in lymph nodes detection was 84.5%, 94.4%, and 91% for CT and 95%, 98.9%, and 95.6% for MRI. High agreement was observed between CT and MRI regarding the number and size of positive lymph nodes and for disease staging. MRI identified eight more extra-nodal lesions than CT. In the subgroup of 20 patients, PET/CT did not show a significant superiority in sensitivity, specificity, accuracy, and staging ability than CT and MRI. (4) Conclusions: Our study demonstrates a mild superiority of MRI over CT in lymphoma staging. Although PET/CT remains the reference standard, MRI demonstrated a similar diagnostic accuracy, with the added value of being radiation-free. View Full-Text
Keywords: diffusion weighted imaging; MRI; PET/CT; CT; Hodgkin lymphoma; non-Hodgkin lymphoma; staging diffusion weighted imaging; MRI; PET/CT; CT; Hodgkin lymphoma; non-Hodgkin lymphoma; staging
MDPI and ACS Style

Maccioni, F.; Calabrese, A.; Manganaro, L.; de Felice, C.; Cardaccio, S.; Lopez, M.; Cleri, A.; Capriotti, G.; Petrucci, L.; Catalano, C.; Pulsoni, A. MRI versus CT and PET/CT in the Preoperative Assessment of Hodgkin and Non-Hodgkin Lymphomas. Hemato 2021, 2, 635-644. https://0-doi-org.brum.beds.ac.uk/10.3390/hemato2040041

AMA Style

Maccioni F, Calabrese A, Manganaro L, de Felice C, Cardaccio S, Lopez M, Cleri A, Capriotti G, Petrucci L, Catalano C, Pulsoni A. MRI versus CT and PET/CT in the Preoperative Assessment of Hodgkin and Non-Hodgkin Lymphomas. Hemato. 2021; 2(4):635-644. https://0-doi-org.brum.beds.ac.uk/10.3390/hemato2040041

Chicago/Turabian Style

Maccioni, Francesca, Alessandro Calabrese, Lucia Manganaro, Carlo de Felice, Sara Cardaccio, Mariangela Lopez, Arianna Cleri, Gabriela Capriotti, Luigi Petrucci, Carlo Catalano, and Alessandro Pulsoni. 2021. "MRI versus CT and PET/CT in the Preoperative Assessment of Hodgkin and Non-Hodgkin Lymphomas" Hemato 2, no. 4: 635-644. https://0-doi-org.brum.beds.ac.uk/10.3390/hemato2040041

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