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Review

Shugoshin: From the Perspective of Clinical Disorders

1
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, CA 94143, USA
2
School of the Environment, Florida Agriculture and Mechanical University, Tallahassee, FL 32307, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Claudio Maia
Received: 27 March 2021 / Revised: 7 May 2021 / Accepted: 16 June 2021 / Published: 25 June 2021
Proper and timely segregation of the cellular genome is a prime requirement of all cell division programs. Mis-segregation of chromosomes and the resulting aneuploidy lead to several clinical consequences. Over the years, shugoshin has emerged as a key protein factor involved in the segregation of genetic material in dividing cells. Deletion or an altered level of shugoshin is reported in several human malignancies; as a result, shugoshin is now emerging as an important tumor-associated gene and a possible target for cancer therapy. Apart from its role in cancer, recent studies have also shown the involvement of shugoshin in several other clinical disorders. In this review, we aim to highlight the clinical relevance of shugoshin. View Full-Text
Keywords: shugoshin; tumor suppressor; cancer; oncogene; tumor-associated gene shugoshin; tumor suppressor; cancer; oncogene; tumor-associated gene
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MDPI and ACS Style

Kumar, R.; Agarwal, M. Shugoshin: From the Perspective of Clinical Disorders. BioChem 2021, 1, 51-59. https://0-doi-org.brum.beds.ac.uk/10.3390/biochem1020006

AMA Style

Kumar R, Agarwal M. Shugoshin: From the Perspective of Clinical Disorders. BioChem. 2021; 1(2):51-59. https://0-doi-org.brum.beds.ac.uk/10.3390/biochem1020006

Chicago/Turabian Style

Kumar, Ravinder, and Meenakshi Agarwal. 2021. "Shugoshin: From the Perspective of Clinical Disorders" BioChem 1, no. 2: 51-59. https://0-doi-org.brum.beds.ac.uk/10.3390/biochem1020006

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