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Article

Field Evaluation of Preventive Efficacy of Monthly Multimodal Prophylactic Treatment (Milbactor® and Vectra® 3D) against Dirofilaria spp. in Dogs

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IRD, AP-HM, MEPHI, Aix Marseille University, IHU Méditerranée Infection, 19-21, Bd Jean Moulin, CEDEX 05, 13385 Marseille, France
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IHU Méditerranée Infection, Assistance Publique-Hôpitaux de Marseille, 19-21, Bd Jean Moulin, CEDEX 05, 13385 Marseille, France
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Animal Epidemiology Expert Group, French Military Health Service, 37100 Tours, France
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Ceva Santé Animale, 10, Av de la Ballastière, 33500 Libourne, France
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Authors to whom correspondence should be addressed.
Academic Editors: Maurizio Francesco Brivio and Geoff Hide
Parasitologia 2021, 1(3), 130-136; https://doi.org/10.3390/parasitologia1030014
Received: 30 June 2021 / Revised: 20 July 2021 / Accepted: 22 July 2021 / Published: 30 July 2021
Dirofilaria immitis and Dirofilaria repens are mosquito-borne pathogens responsible for dirofilariasis in humans and animals. Their transmission and spread depend on the activity of vectors and the frequency of hosts in a given area. Here, we investigated the efficacy of a monthly multimodal prophylactic (MMP) strategy against canine dirofilariasis on Corsica Island (France). The study was conducted as evidence of an efficacy trial in which eighty dogs were divided into two groups: (i) one test group consisted of 25 dogs under the MMP [per-os administration of 1.5 tablets of milbemycin-oxime-praziquantel (Milbactor®) and a topical line-on application of a 3.6 mL solution of dinotefuran-permethrin-pyriproxyfen (Vectra® 3D)] and (ii) a control group under different real-life prophylactic treatments (RLP) based on the use of ectoparasiticides (different formulations: deltamethrin, fluralaner, fipronil) and/or macrocyclic lactone-based products (milbemycin-oxime/praziquantel, milbemycin-oxime, moxidectin) during the period from June to October 2017. All animals were followed up for one year, with blood collected at day 0, with follow-up at 6 and 12 months. Samples were tested for Dirofilaria spp. by species-specific qPCR. At the end of the study, no new case of Dirofilaria spp. infection was detected in the test group. However, the cumulative incidence of Dirofilaria spp. infection was 16.4% (n = 9; p = 0.027) in the control group. The data illustrate that, in contrast to RLP treatment, which failed to protect at least 16.4% of dogs, the MMP based on the simultaneous administration of milbemycin oxime-praziquantel and dinotefuran-permethrin-pyriproxyfen efficiently protects dogs in a high-risk area from Dirofilaria spp. infection. View Full-Text
Keywords: dog; Dirofilaria spp.; multimodal prophylaxis; prevention dog; Dirofilaria spp.; multimodal prophylaxis; prevention
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MDPI and ACS Style

Laidoudi, Y.; Medkour, H.; Tahir, D.; Dahmana, H.; Marié, J.-L.; Varloud, M.; Mediannikov, O.; Davoust, B. Field Evaluation of Preventive Efficacy of Monthly Multimodal Prophylactic Treatment (Milbactor® and Vectra® 3D) against Dirofilaria spp. in Dogs. Parasitologia 2021, 1, 130-136. https://0-doi-org.brum.beds.ac.uk/10.3390/parasitologia1030014

AMA Style

Laidoudi Y, Medkour H, Tahir D, Dahmana H, Marié J-L, Varloud M, Mediannikov O, Davoust B. Field Evaluation of Preventive Efficacy of Monthly Multimodal Prophylactic Treatment (Milbactor® and Vectra® 3D) against Dirofilaria spp. in Dogs. Parasitologia. 2021; 1(3):130-136. https://0-doi-org.brum.beds.ac.uk/10.3390/parasitologia1030014

Chicago/Turabian Style

Laidoudi, Younes, Hacène Medkour, Djamel Tahir, Handi Dahmana, Jean-Lou Marié, Marie Varloud, Oleg Mediannikov, and Bernard Davoust. 2021. "Field Evaluation of Preventive Efficacy of Monthly Multimodal Prophylactic Treatment (Milbactor® and Vectra® 3D) against Dirofilaria spp. in Dogs" Parasitologia 1, no. 3: 130-136. https://0-doi-org.brum.beds.ac.uk/10.3390/parasitologia1030014

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