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Article

CdSe-ZnO Core–Shell Quantum Dots for Protein Detection: A Potential Sensing Platform

1
Center for Materials Research, Norfolk State University, 700 Park Ave., Norfolk, VA 23504, USA
2
Advance Material Solution, 2608 Horse Pasture Road, Suite 101, Virginia Beach, VA 23453, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Frank Shi
Nanomanufacturing 2021, 1(1), 3-13; https://doi.org/10.3390/nanomanufacturing1010002
Received: 10 March 2021 / Revised: 2 April 2021 / Accepted: 6 April 2021 / Published: 9 April 2021
A highly sensitive biosensing platform comprised of CdSe-ZnO core–shell nanostructures for targeted applications in protein detection is demonstrated. This innovative technique uses a microwave-assisted thermal decomposition method to produce a rapid, less hazardous, and user-friendly procedure to synthesize a semiconductor core surrounded by nanometer-thick metal oxide shells. The benefit of using a metal oxide shell includes mitigating the toxicity of the CdSe core, thus increasing its biocompatibility and minimizing its photochemical corrosion and oxidation. We present a simple one-pot microwave-assisted protocol for the formation of CdSe-ZnO core–shell quantum dots (QDs). These QDs optimize the recognition limit of bovine serum albumin (BSA) protein through a spectral signal at a considerably low concentration (2.5 × 10−6 M), thus demonstrating its potential to become a highly effective surface-plasmon-enhanced Raman spectroscopy (SERS)-like sensing platform. We report a QD material that can mimic a strong SERS-like behavior due to charge transfer affecting the local electric field. View Full-Text
Keywords: biosensing; quantum dots; surface plasmons; protein detection biosensing; quantum dots; surface plasmons; protein detection
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MDPI and ACS Style

Jenrette, E.A.; Farrell, M.J.; Flowers, J.A.; Pradhan, A.K. CdSe-ZnO Core–Shell Quantum Dots for Protein Detection: A Potential Sensing Platform. Nanomanufacturing 2021, 1, 3-13. https://0-doi-org.brum.beds.ac.uk/10.3390/nanomanufacturing1010002

AMA Style

Jenrette EA, Farrell MJ, Flowers JA, Pradhan AK. CdSe-ZnO Core–Shell Quantum Dots for Protein Detection: A Potential Sensing Platform. Nanomanufacturing. 2021; 1(1):3-13. https://0-doi-org.brum.beds.ac.uk/10.3390/nanomanufacturing1010002

Chicago/Turabian Style

Jenrette, Erin A., Monique J. Farrell, Jasmin A. Flowers, and Aswini K. Pradhan 2021. "CdSe-ZnO Core–Shell Quantum Dots for Protein Detection: A Potential Sensing Platform" Nanomanufacturing 1, no. 1: 3-13. https://0-doi-org.brum.beds.ac.uk/10.3390/nanomanufacturing1010002

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