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A New Nanomaterial Based Biosensor for MUC1 Biomarker Detection in Early Diagnosis, Tumor Progression and Treatment of Cancer

1
Biomedical Technology Department, Graduate School of Applied and Natural Sciences, Ege University, Izmir 35040, Turkey
2
Department of Biochemistry, Faculty of Science, Ege University, Izmir 35040, Turkey
*
Author to whom correspondence should be addressed.
Academic Editor: Andres Castellanos-Gomez
Received: 14 March 2021 / Revised: 14 April 2021 / Accepted: 27 April 2021 / Published: 13 May 2021
(This article belongs to the Special Issue Feature Papers for Nanomanufacturing)
Early detection of cancer disease is vital to the successful treatment, follow-up and survival of patients, therefore sensitive and specific methods are still required. Mucin 1 (MUC1) is a clinically approved biomarker for determining the cancer that is a type I transmembrane protein with a dense glycosylated extracellular domain extending from the cell surface to 200–500 nm. In this study, nanopolymers were designed with a lectin affinity-based recognition system for MUC1 detection as a bioactive layer on electrochemical biosensor electrode surfaces. They were synthesized using a mini emulsion polymerization method and derivatized with triethoxy-3-(2-imidazolin-1-yl) propylsilane (IMEO) and functionalized with Concanavalin a Type IV (Con A) lectin. Advanced characterization studies of nanopolymers were performed. The operating conditions of the sensor system have been optimized. Biosensor validation studies were performed. Real sample blood serum was analyzed and this new method compared with a commercially available medical diagnostic kit (Enzyme-Linked ImmunoSorbent Assay-ELISA). The new generation nanopolymeric material has been shown to be an affordable, sensitive, reliable and rapid device with 0.1–100 U/mL linear range and 20 min response time. View Full-Text
Keywords: MUC1; cancer biosensor; polymeric nanomaterials MUC1; cancer biosensor; polymeric nanomaterials
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MDPI and ACS Style

Ulucan-Karnak, F.; Akgöl, S. A New Nanomaterial Based Biosensor for MUC1 Biomarker Detection in Early Diagnosis, Tumor Progression and Treatment of Cancer. Nanomanufacturing 2021, 1, 14-38. https://0-doi-org.brum.beds.ac.uk/10.3390/nanomanufacturing1010003

AMA Style

Ulucan-Karnak F, Akgöl S. A New Nanomaterial Based Biosensor for MUC1 Biomarker Detection in Early Diagnosis, Tumor Progression and Treatment of Cancer. Nanomanufacturing. 2021; 1(1):14-38. https://0-doi-org.brum.beds.ac.uk/10.3390/nanomanufacturing1010003

Chicago/Turabian Style

Ulucan-Karnak, Fulden, and Sinan Akgöl. 2021. "A New Nanomaterial Based Biosensor for MUC1 Biomarker Detection in Early Diagnosis, Tumor Progression and Treatment of Cancer" Nanomanufacturing 1, no. 1: 14-38. https://0-doi-org.brum.beds.ac.uk/10.3390/nanomanufacturing1010003

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