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Article

Sinapic Acid Release at the Cell Level by Incorporation into Nanoparticles: Experimental Evidence Using Biomembrane Models

Department of Drug and Health Sciences, University of Catania, Viale Andrea Doria 6, 95125 Catania, Italy
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Author to whom correspondence should be addressed.
Academic Editor: Horacio Bach
Received: 29 June 2021 / Revised: 14 July 2021 / Accepted: 27 July 2021 / Published: 31 July 2021
(This article belongs to the Section Microscale Biology and Medicines)
Sinapic acid (SA), belonging to the phenylpropanoid family, and its derivatives are secondary metabolites found in the plant kingdom. In recent years, they have drawn attention because of their various biological activities, including neuroprotective effects. In this study, SA was incorporated into two different nanoparticle systems, solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC). The influence of different concentrations of SA on the nanoparticle systems was evaluated. It was studied the efficacy of the nanoparticle systems to release the active ingredient at cell level through the use of models of biological membranes represented by multilamellar vesicles (MLV) of dimyristoylphosphatidylcholine (DMPC) and conducting kinetic studies by placing in contact SLN and NLC, both unloaded and loaded with two different amounts of SA, with the same biological membrane model. Differential scanning calorimetry (DSC) was used for these studies. The results indicated a different distribution of SA within the two nanoparticle systems and that NLC are able to incorporate and release SA inside the structure of the biological membrane model. View Full-Text
Keywords: lipid nanocarriers; SLN; NLC; DSC; liposomes; MLV lipid nanocarriers; SLN; NLC; DSC; liposomes; MLV
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MDPI and ACS Style

Torrisi, C.; Morgante, A.; Malfa, G.; Acquaviva, R.; Castelli, F.; Pignatello, R.; Sarpietro, M.G. Sinapic Acid Release at the Cell Level by Incorporation into Nanoparticles: Experimental Evidence Using Biomembrane Models. Micro 2021, 1, 120-128. https://0-doi-org.brum.beds.ac.uk/10.3390/micro1010009

AMA Style

Torrisi C, Morgante A, Malfa G, Acquaviva R, Castelli F, Pignatello R, Sarpietro MG. Sinapic Acid Release at the Cell Level by Incorporation into Nanoparticles: Experimental Evidence Using Biomembrane Models. Micro. 2021; 1(1):120-128. https://0-doi-org.brum.beds.ac.uk/10.3390/micro1010009

Chicago/Turabian Style

Torrisi, Cristina, Arianna Morgante, Giuseppe Malfa, Rosaria Acquaviva, Francesco Castelli, Rosario Pignatello, and Maria G. Sarpietro 2021. "Sinapic Acid Release at the Cell Level by Incorporation into Nanoparticles: Experimental Evidence Using Biomembrane Models" Micro 1, no. 1: 120-128. https://0-doi-org.brum.beds.ac.uk/10.3390/micro1010009

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