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Antibody Response against the SARS-CoV-2 Nucleocapsid Protein and Its Subdomains—Identification of Pre-Immunization Status by Human Coronaviruses with Multipanel Nucleocapsid Fragment Immunoblotting
 
 
Case Report
Peer-Review Record

A New Viral Coinfection: SARS-CoV-2 Pneumonia and Cytomegalovirus Pneumonitis in a Renal Transplant Recipient

by Abdullah S. Shaikh 1,*, Hila Shaim 1, Maria A. Caravedo 2, Karen M. Ong 1 and David Reynoso 2
Reviewer 1:
Reviewer 2:
Reviewer 3: Anonymous
Submission received: 1 June 2021 / Revised: 30 June 2021 / Accepted: 4 July 2021 / Published: 7 July 2021

Round 1

Reviewer 1 Report

The title is not appropriate. If the case was truly unique then it would be of little interest. The conclusion correctly notes that the combination should be anticipated in high risk cases. The title should reflect this.

Author Response

Thank you for your feedback. I will change the title to "A New Viral Coinfection: SARS-CoV-2 Pneumonia and Cytomegalovirus Pneumonitis in a Renal Transplant Recipient."

Reviewer 2 Report

A great paper, no suggested changes.

Author Response

Thank you for your feedback!

Reviewer 3 Report

Authors presented interesting case of  the CMV and SARS-CoV-2 coinfection complicated with CMV resistance. It seems that rather prolonged CMV replication was associated with risk factor for COVID-19. Suboptimal dose of valgacyclovir is associated with development of resistance. The risk was aggravated by recipient's seronegative CMV status.

Authors did not provide information regarding immunosuppression modification. I agree that CNI may have positive effect on cytokine storm but not MMF especially in the setting of severe lucopenia. MMF sholuld be withdrawn  and cyclosporine dose should be reduced. There  is lack of this information.

 

Author Response

Thank you for your feedback! I have added the changes in his immunosuppression into the paper. 

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