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What Is the Estimated COVID-19 Reproduction Number and the Proportion of the Population That Needs to Be Immunized to Achieve Herd Immunity in Malaysia? A Mathematical Epidemiology Synthesis

1
Clinical Research Center, Seberang Jaya Hospital, Ministry of Health Malaysia, Penang 13700, Malaysia
2
Medical Department, Seberang Jaya Hospital, Penang 13700, Malaysia
*
Author to whom correspondence should be addressed.
Academic Editor: Joan Puig-Barberà
Received: 2 March 2021 / Revised: 27 March 2021 / Accepted: 7 April 2021 / Published: 1 June 2021
We aimed to determine Malaysia’s COVID-19 reproduction number and herd immunity threshold through a mathematical epidemiology synthesis. Using time-series incidence data, the time-dependent reproduction number (Rt) was yielded over time during the COVID-19 containment measures in Malaysia. The value of Rt at the beginning of the epidemic and prior to any interventions in place was used to determine the proportion of the population that needs to be immunized to achieve herd immunity. Rt was strongly influenced by interventions being put in place. We established that at least 74% of the Malaysian population needs to be vaccinated to achieve herd immunity against COVID-19. This threshold estimate is somewhat influenced by the availability of an efficacious vaccine. A vaccine with 95% efficacy would approximately synthesize a herd immunity threshold of 78%. We conclude that Rt is a valid estimator to determine the effectiveness of control measures and a parameter of use to synthesize herd immunity thresholds in the current COVID-19 pandemic. View Full-Text
Keywords: COVID-19; reproduction number; herd immunity; vaccine; Malaysia COVID-19; reproduction number; herd immunity; vaccine; Malaysia
MDPI and ACS Style

Ganasegeran, K.; Ch’ng, A.S.H.; Looi, I. What Is the Estimated COVID-19 Reproduction Number and the Proportion of the Population That Needs to Be Immunized to Achieve Herd Immunity in Malaysia? A Mathematical Epidemiology Synthesis. COVID 2021, 1, 13-19. https://0-doi-org.brum.beds.ac.uk/10.3390/covid1010003

AMA Style

Ganasegeran K, Ch’ng ASH, Looi I. What Is the Estimated COVID-19 Reproduction Number and the Proportion of the Population That Needs to Be Immunized to Achieve Herd Immunity in Malaysia? A Mathematical Epidemiology Synthesis. COVID. 2021; 1(1):13-19. https://0-doi-org.brum.beds.ac.uk/10.3390/covid1010003

Chicago/Turabian Style

Ganasegeran, Kurubaran, Alan S.H. Ch’ng, and Irene Looi. 2021. "What Is the Estimated COVID-19 Reproduction Number and the Proportion of the Population That Needs to Be Immunized to Achieve Herd Immunity in Malaysia? A Mathematical Epidemiology Synthesis" COVID 1, no. 1: 13-19. https://0-doi-org.brum.beds.ac.uk/10.3390/covid1010003

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