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Persistence of Anti-SARS-CoV-2 Antibodies Six Months after Infection in an Outbreak with Five Hundred COVID-19 Cases in Borriana (Spain): A Prospective Cohort Study

1
Emergency Service Hospital de la Plana, 12540 Vila-real, Spain
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Vaccines Research Area FISABIO, 46020 Valencia, Spain
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Public Health Center, 12540 Castelló de la Plana, Spain
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Health Centers I and II, 12540 Borriana, Spain
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Carinyena Health Center, 12540 Vila-real, Spain
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Health Center, 12540 Onda, Spain
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Health Center, 12540 La Vall d’Uixó, Spain
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Villa Fátima School, 12540 Borriana, Spain
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Department of Health Science, Public University Navarra, 31006 Pamplona, Spain
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Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Stefano Aquaro
Received: 3 June 2021 / Revised: 16 June 2021 / Accepted: 25 June 2021 / Published: 30 June 2021
In March 2020, several mass gathering events were related to the Falles festival in Borriana (Spain), resulting in a 536 laboratory-confirmed COVID-19 cases outbreak among participants. This article estimates anti-SARS-CoV-2 antibodies persistence six months after and factors associated with antibody response. A prospective population-based cohort study was carried out by the Public Health Centre of Castellon and the Emergency and Clinical Analysis and Microbiology Services of Hospital de la Plana in Vila-real. In October 2020, a seroepidemiologic study was used to estimate the persistence of anti-SARS-CoV-2 antibodies against nucleocapsid protein (N) by an electrochemiluminescence immunoassay (ECLIA) was implemented. We enrolled 484 (90.2%) of the 536 members of the initial outbreak cohort and detected persistent antibodies in 479 (99%) without reinfection episodes. Five participants had a negative antibody test. Factors associated with a negative result were a lower body mass index (BMI), and less contact with other COVID-19 cases. Among the 469 participants with two ECLIA tests, 96 (20.5%) had an increase of antibodies and 373 (79.5%) a decline. Increased antibodies were associated with older age, higher BMI, more severe illness, and low current smokers. Our results show that after a COVID-19 infection, a high proportion of cases maintain detectable anti-SARS-CoV-2 antibodies. View Full-Text
Keywords: SARS-CoV-2; COVID-19; antibodies; cohort; population-based; body mass index; ECLIA SARS-CoV-2; COVID-19; antibodies; cohort; population-based; body mass index; ECLIA
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MDPI and ACS Style

Domènech-Montoliu, S.; Puig-Barberà, J.; Pac-Sa, M.R.; Vidal-Utrillas, P.; Latorre-Poveda, M.; Del Rio-González, A.; Ferrando-Rubert, S.; Ferrer-Abad, G.; Sánchez-Urbano, M.; Aparisi-Esteve, L.; Badenes-Marques, G.; Cervera-Ferrer, B.; Clerig-Arnau, U.; Dols-Bernad, C.; Fontal-Carcel, M.; Gomez-Lanas, L.; Jovani-Sales, D.; León-Domingo, M.C.; Llopico-Vilanova, M.D.; Moros-Blasco, M.; Notari-Rodríguez, C.; Ruíz-Puig, R.; Valls-López, S.; Arnedo-Pena, A. Persistence of Anti-SARS-CoV-2 Antibodies Six Months after Infection in an Outbreak with Five Hundred COVID-19 Cases in Borriana (Spain): A Prospective Cohort Study. COVID 2021, 1, 71-82. https://0-doi-org.brum.beds.ac.uk/10.3390/covid1010006

AMA Style

Domènech-Montoliu S, Puig-Barberà J, Pac-Sa MR, Vidal-Utrillas P, Latorre-Poveda M, Del Rio-González A, Ferrando-Rubert S, Ferrer-Abad G, Sánchez-Urbano M, Aparisi-Esteve L, Badenes-Marques G, Cervera-Ferrer B, Clerig-Arnau U, Dols-Bernad C, Fontal-Carcel M, Gomez-Lanas L, Jovani-Sales D, León-Domingo MC, Llopico-Vilanova MD, Moros-Blasco M, Notari-Rodríguez C, Ruíz-Puig R, Valls-López S, Arnedo-Pena A. Persistence of Anti-SARS-CoV-2 Antibodies Six Months after Infection in an Outbreak with Five Hundred COVID-19 Cases in Borriana (Spain): A Prospective Cohort Study. COVID. 2021; 1(1):71-82. https://0-doi-org.brum.beds.ac.uk/10.3390/covid1010006

Chicago/Turabian Style

Domènech-Montoliu, Salvador, Joan Puig-Barberà, Maria R. Pac-Sa, Paula Vidal-Utrillas, Marta Latorre-Poveda, Alba Del Rio-González, Sara Ferrando-Rubert, Gema Ferrer-Abad, Manuel Sánchez-Urbano, Laura Aparisi-Esteve, Gema Badenes-Marques, Belén Cervera-Ferrer, Ursula Clerig-Arnau, Claudia Dols-Bernad, Maria Fontal-Carcel, Lorna Gomez-Lanas, David Jovani-Sales, Maria C. León-Domingo, Maria D. Llopico-Vilanova, Mercedes Moros-Blasco, Cristina Notari-Rodríguez, Raquel Ruíz-Puig, Sonia Valls-López, and Alberto Arnedo-Pena. 2021. "Persistence of Anti-SARS-CoV-2 Antibodies Six Months after Infection in an Outbreak with Five Hundred COVID-19 Cases in Borriana (Spain): A Prospective Cohort Study" COVID 1, no. 1: 71-82. https://0-doi-org.brum.beds.ac.uk/10.3390/covid1010006

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