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Short Biography of Author
|Pier Paolo Claudio completed a Medicine and Surgery Master Degree in 1989 at the University Federico II, in Naples, Italy, graduating summa cum laude, on the basis of a public defense of the thesis dissertation: “Selective Endo-Arterial Chemotherapy for Advanced Head & Neck Tumors”. He also completed a doctorate in Maxillofacial Sciences and Maxillofacial Surgery in 1994 at the University Federico II, in Naples, Italy, graduating summa cum laude, on the basis of a public defense of the thesis dissertation: “Nasopharyngeal Carcinoma: Epidemiology, Clinic, and New Frontiers of Research”. Following two years of postdoctoral fellowship at Temple University and two more years at Thomas Jefferson University, in Philadelphia, he joined the faculty at Thomas Jefferson University as assistant professor in 1998, and was promoted to associate professor in 2000. At Thomas Jefferson University for his research he was awarded an international Patent for the use of adenoviral gene therapy in the prevention of restenosis after angioplasty. In 2002, he joined the Temple University faculty as associate professor and director of the Molecular Therapeutic Program where he expanded his research on viral gene therapy and developed a novel delivery system for safer gene transfer protocols that employes the unique characteristics of ultrasound contrast agents to deliver therapeutic genes to a diseased tissue. For this research he was awarded an international Patent in 2013 for the theranostic use of ultrasound contrast agents to deliver therapeutic genes to tissues. In 2006, he joined the faculty at Marshall University as associate professor where he gained tenure and became director of the Translational Genomics Institute Laboratories at the Joan C. Edwards Cancer Center in Huntington West Virginia where he focused his research on the effects that chemotherapy drugs and various diet components have on the growth and survival of the root of cancer, i.e., the cancer stem cells (CSCs). Between 2006 and 2009, he co-developed a cell culture method, which enables the selection and proliferation of adult stem cells from normal human tissues and of cancer stem cells (CSCs) from patient tumor biopsies. This method was awarded three international Patents between 2015 and 2016, for the production of adult stem cells and cancer stem cells and for their use to screen chemotherapeutic agents and treating cancer. Using these methods, he co-developed the ChemoID assay, which is a Cancer Stem Cell cytotoxicity assay to predict more effective chemotherapies against cancer. The test is currently being prospectively used in two Phase-III randomized clinical trials to guide chemotherapy treatments for recurrent glioblastoma and recurrent ovarian cancer patients (NCT03949283 and NCT03632135). In 2015, Dr. Claudio joined the faculty at the University of Mississippi and the Cancer Center & Resdearch Institute as full professor with tenure, Director of translational cancer research laboratories and Director of the Stem Cell Core with a team of researchers focused at translating into practice several botanical extracts with anticancer properties. Currently, the focus of his laboratory is to bridge and integrate the basic cancer research conducted at the National Center for Natural Product Research (NCNPR), the School of Pharmacy, the University of Mississippi School of Medicine, and the Cancer Center & Research Institute in Jackson with various clinical oncology research groups, surgical oncologists, radiation oncologists, and radiologists in an effort to translate discoveries and laboratory work conducted at the University into clinical evaluations and personalized medicine. Dr. Claudio published over 180 manuscripts in peer-reviewed scientific journals and 13 book chapters on cancer therapeutics, and he is the editor of four books on cancer.|
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