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International Journal of Translational Medicine: An Interdisciplinary Open Access Journal to Publish Your Biomedical Research with a “Bench-to-Bedside” Approach
Review

Development of Multilayer Mesenchymal Stem Cell Cell Sheets

Emmaus Life Sciences, Inc., 21250 Hawthorne Blvd., Suite 800, Torrance, CA 90503, USA
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Academic Editor: Pier Paolo Claudio
Int. J. Transl. Med. 2021, 1(1), 4-24; https://0-doi-org.brum.beds.ac.uk/10.3390/ijtm1010002
Received: 11 March 2021 / Revised: 28 April 2021 / Accepted: 8 May 2021 / Published: 24 May 2021
Cell and gene therapies have been developing dramatically over the past decade. To face and adapt to the development of these new therapies, the Food and Drug Administration (FDA) wrote and updated new guidelines from 2016 and keep updating them. Mesenchymal stem cells (MSCs) are the most used cells for treatment, far ahead from the induced pluripotent stem cells (iPSCs), based on registered clinical trials at clinicaltrials.gov. They are widely used because of their differentiation capacity and their anti-inflammatory properties, but some controversies still require clear answers. Additional studies are needed to determine the dosage, the number, and the route of injections (location and transplantation method), and if allogenic MSCs are safe compared to autologous MSC injection, including their long-term effect. In this review, we summarize the research our company is conducting with the adipose stromal cells in engineering cell sheets and their potential application. View Full-Text
Keywords: mesenchymal stem cells; cell sheet; cryopreservation mesenchymal stem cells; cell sheet; cryopreservation
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MDPI and ACS Style

Ochiai, J.; Niihara, Y.; Oliva, J. Development of Multilayer Mesenchymal Stem Cell Cell Sheets. Int. J. Transl. Med. 2021, 1, 4-24. https://0-doi-org.brum.beds.ac.uk/10.3390/ijtm1010002

AMA Style

Ochiai J, Niihara Y, Oliva J. Development of Multilayer Mesenchymal Stem Cell Cell Sheets. International Journal of Translational Medicine. 2021; 1(1):4-24. https://0-doi-org.brum.beds.ac.uk/10.3390/ijtm1010002

Chicago/Turabian Style

Ochiai, Jun, Yutaka Niihara, and Joan Oliva. 2021. "Development of Multilayer Mesenchymal Stem Cell Cell Sheets" International Journal of Translational Medicine 1, no. 1: 4-24. https://0-doi-org.brum.beds.ac.uk/10.3390/ijtm1010002

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