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Clusters, Assemblies and Aggregates of Tumor Cells in the Blood of Breast Cancer Patients; Composition, Mode of Action, Detection and Impact on Metastasis and Survival

Molecular and Translational Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, Roentgena 5, 02-781 Warsaw, Poland
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Academic Editor: Pier Paolo Claudio
Int. J. Transl. Med. 2021, 1(1), 55-68; https://0-doi-org.brum.beds.ac.uk/10.3390/ijtm1010005
Received: 6 May 2021 / Revised: 19 May 2021 / Accepted: 21 May 2021 / Published: 4 June 2021
Circulating tumor cells (CTCs) are gaining momentum as a diagnostic tool and therapeutic target. CTC clusters are more metastatic, but harder to study and characterize, because they are rare and the methods of isolation are mostly focused on single CTCs. This review highlights the recent advances to our understanding of tumor cell clusters with the emphasis on their composition, origin, biology, methods of detection, and impact on metastasis and survival. New approaches to therapy, based on cluster characteristics are also described. View Full-Text
Keywords: circulating tumor cells; clusters; breast cancer; metastasis circulating tumor cells; clusters; breast cancer; metastasis
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MDPI and ACS Style

Smietanka, U.; Szostakowska-Rodzos, M.; Tabor, S.; Fabisiewicz, A.; Grzybowska, E.A. Clusters, Assemblies and Aggregates of Tumor Cells in the Blood of Breast Cancer Patients; Composition, Mode of Action, Detection and Impact on Metastasis and Survival. Int. J. Transl. Med. 2021, 1, 55-68. https://0-doi-org.brum.beds.ac.uk/10.3390/ijtm1010005

AMA Style

Smietanka U, Szostakowska-Rodzos M, Tabor S, Fabisiewicz A, Grzybowska EA. Clusters, Assemblies and Aggregates of Tumor Cells in the Blood of Breast Cancer Patients; Composition, Mode of Action, Detection and Impact on Metastasis and Survival. International Journal of Translational Medicine. 2021; 1(1):55-68. https://0-doi-org.brum.beds.ac.uk/10.3390/ijtm1010005

Chicago/Turabian Style

Smietanka, Urszula, Małgorzata Szostakowska-Rodzos, Sylwia Tabor, Anna Fabisiewicz, and Ewa A. Grzybowska 2021. "Clusters, Assemblies and Aggregates of Tumor Cells in the Blood of Breast Cancer Patients; Composition, Mode of Action, Detection and Impact on Metastasis and Survival" International Journal of Translational Medicine 1, no. 1: 55-68. https://0-doi-org.brum.beds.ac.uk/10.3390/ijtm1010005

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