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The Metastatic Capacity of Melanoma Reveals Alternative Pathways of Cancer Dissemination

Department of Molecular and Translational Medicine, University of Brescia, Via Branze 39, 25123 Brescia, Italy
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Author to whom correspondence should be addressed.
Academic Editor: Pier Paolo Claudio
Int. J. Transl. Med. 2021, 1(3), 163-174; https://0-doi-org.brum.beds.ac.uk/10.3390/ijtm1030012
Received: 5 August 2021 / Revised: 21 September 2021 / Accepted: 28 September 2021 / Published: 1 October 2021
(This article belongs to the Special Issue Advances in the Angiogenic Field)
For many years the growth of solid tumors has been associated with their vascularization. The new vessels are needed to deliver oxygen and nutrients within the tumor mass. At the same time, these poorly stabilized vessels act as “Trojan horses” and open a way out for cancer cells. More recently, tumors have been identified whose growth appears to be independent of endothelial cell activity. Here we describe the ability of cancer cells to differentiate and reorganize themself in channels similar to blood vessels containing blood flow, overcoming the need for the angiogenic process of tumor vascularization. Together with the new vessels arising both from angiogenic and vasculogenic processes, these vessel-like structures can be exploited by tumor cells as a guide for migration and metastatic dissemination. In addition to classical intravascular dissemination, cancer cells can acquire pericytic features, interact with the endothelial basal lamina and migrate toward vessels or outside of the vessels. As expected, these alternative tumor behaviors assume greater importance if we consider that drugs with anti-angiogenic action directed against endothelial cells or their ligands are currently used in cancer therapy. View Full-Text
Keywords: metastasis; extravascular migratory metastasis; vascular mimicry; Epithelial-to-Mesenchymal Transition (EMT); angiotropism metastasis; extravascular migratory metastasis; vascular mimicry; Epithelial-to-Mesenchymal Transition (EMT); angiotropism
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MDPI and ACS Style

Corsini, M.; Ravelli, C.; Grillo, E.; Mitola, S. The Metastatic Capacity of Melanoma Reveals Alternative Pathways of Cancer Dissemination. Int. J. Transl. Med. 2021, 1, 163-174. https://0-doi-org.brum.beds.ac.uk/10.3390/ijtm1030012

AMA Style

Corsini M, Ravelli C, Grillo E, Mitola S. The Metastatic Capacity of Melanoma Reveals Alternative Pathways of Cancer Dissemination. International Journal of Translational Medicine. 2021; 1(3):163-174. https://0-doi-org.brum.beds.ac.uk/10.3390/ijtm1030012

Chicago/Turabian Style

Corsini, Michela, Cosetta Ravelli, Elisabetta Grillo, and Stefania Mitola. 2021. "The Metastatic Capacity of Melanoma Reveals Alternative Pathways of Cancer Dissemination" International Journal of Translational Medicine 1, no. 3: 163-174. https://0-doi-org.brum.beds.ac.uk/10.3390/ijtm1030012

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