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Biological Analyses-Derived Translational Findings in the T Cell Receptor Alpha Chain Knockout Mouse as an Experimental Model for Ulcerative Colitis

1
Department of Immunology, Kurume University School of Medicine, Fukuoka 830-0011, Japan
2
Department of Molecular Microbiology and Immunology, Brown University Alpert Medical School, Providence, RI 02912, USA
*
Author to whom correspondence should be addressed.
Academic Editors: François Fenaille, Florence Castelli and Benoit Colsch
Int. J. Transl. Med. 2021, 1(3), 187-204; https://0-doi-org.brum.beds.ac.uk/10.3390/ijtm1030014
Received: 9 October 2021 / Revised: 29 October 2021 / Accepted: 3 November 2021 / Published: 8 November 2021
(This article belongs to the Special Issue Biomarker Discovery in Medical and Health Contexts Using Metabolomics)
Inflammatory bowel disease (IBD) is a group of chronic inflammatory disorders that affects many individuals throughout their lives. Ulcerative colitis (UC) and Crohn’s disease (CD) are two major forms of IBD. Until the early 1990s, a murine model of spontaneous chronic colitis was unavailable. As a major breakthrough in the basic research field of IBD, three genetically manipulated murine chronic colitis models, including interleukin (IL)-2 knockout (KO), IL-10 KO, and T cell receptor alpha chain (TCRα) KO models, were established in 1993. Since then, complicated immunobiological mechanisms during the development of UC have been gradually discovered by utilizing a wide variety of murine models of IBD, including the TCRα KO mouse model. In particular, it has been recognized that four major factors, including enteric, environmental, and immunological factors as well as enteric microbiota are highly and mutually involved in the pathogenesis of UC. As a pioneer of the TCRα KO murine model of UC, our group has identified that the interactions between the unique TCRα-β+ T cell population and antigen-presenting cells, including dendritic cells and B cells, play a key role for the development and regulation of UC-like chronic colitis, respectively. Here we have summarized clinically proven pathogenic and regulatory factors which have been identified by this novel TCRα KO murine model of UC in the past nearly three decades. View Full-Text
Keywords: inflammatory bowel disease; pathogenesis; inflammation; dysbiosis; regulatory factors inflammatory bowel disease; pathogenesis; inflammation; dysbiosis; regulatory factors
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MDPI and ACS Style

Mizoguchi, E.; Sadanaga, T.; Okada, T. Biological Analyses-Derived Translational Findings in the T Cell Receptor Alpha Chain Knockout Mouse as an Experimental Model for Ulcerative Colitis. Int. J. Transl. Med. 2021, 1, 187-204. https://0-doi-org.brum.beds.ac.uk/10.3390/ijtm1030014

AMA Style

Mizoguchi E, Sadanaga T, Okada T. Biological Analyses-Derived Translational Findings in the T Cell Receptor Alpha Chain Knockout Mouse as an Experimental Model for Ulcerative Colitis. International Journal of Translational Medicine. 2021; 1(3):187-204. https://0-doi-org.brum.beds.ac.uk/10.3390/ijtm1030014

Chicago/Turabian Style

Mizoguchi, Emiko, Takayuki Sadanaga, and Toshiyuki Okada. 2021. "Biological Analyses-Derived Translational Findings in the T Cell Receptor Alpha Chain Knockout Mouse as an Experimental Model for Ulcerative Colitis" International Journal of Translational Medicine 1, no. 3: 187-204. https://0-doi-org.brum.beds.ac.uk/10.3390/ijtm1030014

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