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Review

A Systematic Review on the Role of Adrenergic Receptors in Angiogenesis Regulation in Health and Disease

Laboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, 26504 Patras, Greece
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Academic Editor: Stefania Mitola
Int. J. Transl. Med. 2021, 1(3), 353-365; https://0-doi-org.brum.beds.ac.uk/10.3390/ijtm1030021
Received: 30 September 2021 / Revised: 23 November 2021 / Accepted: 26 November 2021 / Published: 30 November 2021
(This article belongs to the Special Issue Advances in the Angiogenic Field)
Angiogenesis is essential during development or when tissue restoration and oxygenation is required. Limited or excessive formation of blood vessels is a hallmark of several pathologies, and many angiogenesis-related pathways are being studied to highlight potential targets for effective angiogenesis-stimulating or inhibiting therapeutic approaches. A few studies point to the adrenergic system as a significant regulator of angiogenesis, directly or indirectly. Functional adrenergic receptors are expressed on endothelial cells and affect their response to the adrenergic system. The latter can also upregulate the release of growth factors by mural cells of the vessel wall, blood cells or cancer cells, thus subsequently affecting endothelial cell functions and angiogenesis. In the present study we summarize up-to-date literature on the known effects of the adrenergic receptors on physiological and pathological angiogenesis. View Full-Text
Keywords: adrenergic receptors; agonists; angiogenesis; antagonists; blood cells; cancer cells; endothelial cells adrenergic receptors; agonists; angiogenesis; antagonists; blood cells; cancer cells; endothelial cells
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MDPI and ACS Style

Xanthopoulos, A.; Daskalopoulou, I.; Frountzi, S.; Papadimitriou, E. A Systematic Review on the Role of Adrenergic Receptors in Angiogenesis Regulation in Health and Disease. Int. J. Transl. Med. 2021, 1, 353-365. https://0-doi-org.brum.beds.ac.uk/10.3390/ijtm1030021

AMA Style

Xanthopoulos A, Daskalopoulou I, Frountzi S, Papadimitriou E. A Systematic Review on the Role of Adrenergic Receptors in Angiogenesis Regulation in Health and Disease. International Journal of Translational Medicine. 2021; 1(3):353-365. https://0-doi-org.brum.beds.ac.uk/10.3390/ijtm1030021

Chicago/Turabian Style

Xanthopoulos, Athanasios, Iliana Daskalopoulou, Sofia Frountzi, and Evangelia Papadimitriou. 2021. "A Systematic Review on the Role of Adrenergic Receptors in Angiogenesis Regulation in Health and Disease" International Journal of Translational Medicine 1, no. 3: 353-365. https://0-doi-org.brum.beds.ac.uk/10.3390/ijtm1030021

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