Marine Animal-Derived Compounds and Autophagy Modulation in Breast Cancer Cells
Abstract
:1. A Brief Insight into Autophagy and Breast Cancer Cells
2. The Marine Animal Species as a Source of Bioactive Molecules
3. Autophagy Modulators from Porifera
4. Autophagy Modulators from Cnidaria
5. Autophagy Modulators from Mollusca
6. Autophagy Modulators from Echinodermata
7. Conclusions
Funding
Institutional Review Board Statement
Informed Consent Statement
Conflicts of Interest
References
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Organism of Origin | Substance | Autophagy-Related Effects |
---|---|---|
Haliclona genus (Porifera) | Papuamine | Accumulation of total LC3 and LC3-II; possible mitophagy |
H. caerulea (Porifera) | Halilectin-3 | Upregulation of MAP1LC3B gene expression; accumulation of LC3-II |
C. celata (Porifera) | Clionamine A-D | increase of cytoplasmic green fluorescent protein (GFP)-LC3 puncta |
Psammaphysilla genus (Porifera) | Psammaplin A | Increase of acidic vacuolar organelles; upregulation of LC3, ATG-3, -5, -7, -12, and beclin-1; downregulation of p62/SQSTM1 protein |
X. esigua (Porifera) | Araguspongine C | Increase of fluorescent autophagosomes; upregulation of total LC3, Beclin-1, ATG-5, -7, and -16L1 |
F. reticulata (Porifera) | Fascaplysin | Increase of acidic vacuolar organelles; upregulation of LC3-II (by 4-chloro-fascaplysin derivative) |
Aaptos genus (Porifera) | Isoaaptamine | Increase of acridine orange-positive vacuoles; upregulation of LC3-II and p62/SQSTM1; downregulation of mTOR |
K. flaccidum (Cnidaria) | 3β,11-dihydroxy-9,11- secogorgost-5-en-9-one | Increase of acidic vesicular organelles; upregulation of LC3-II and p62 |
C. virginica (Mollusca) | N-methylaminoethyl phosphonate | Increase of fluorescent autophagosomes; upregulation of beclin-1 |
A. lixula (Echinodermata) | Cell-free aqueous extracts of the coelomic fluid | Increase of acidic vesicular organelles; upregulation of beclin-1, LC3-II, and total LC3 |
H. tubulosa (Echinodermata) | Cell-free aqueous extracts of the coelomic fluid | Increase of acidic vesicular organelles; upregulation of beclin-1, LC3-II, and total LC3; possible mitophagy |
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Luparello, C. Marine Animal-Derived Compounds and Autophagy Modulation in Breast Cancer Cells. Foundations 2021, 1, 3-20. https://0-doi-org.brum.beds.ac.uk/10.3390/foundations1010002
Luparello C. Marine Animal-Derived Compounds and Autophagy Modulation in Breast Cancer Cells. Foundations. 2021; 1(1):3-20. https://0-doi-org.brum.beds.ac.uk/10.3390/foundations1010002
Chicago/Turabian StyleLuparello, Claudio. 2021. "Marine Animal-Derived Compounds and Autophagy Modulation in Breast Cancer Cells" Foundations 1, no. 1: 3-20. https://0-doi-org.brum.beds.ac.uk/10.3390/foundations1010002