The Identification of the Genetic Components of Autism Spectrum Disorders 2017

© 2018 by the authors; CC BY-NC-ND license

multifactorial inheritance; genetic testing; diagnostic yield; copy number variants; gene sequencing; genomics; G-negative euchromatin; G-positive heterochromatin; chromosome organization; high-resolution chromosome ideograms; protein-coding genes; obesity genes; autism spectrum disorder (ASD) genes; autism spectrum disorder; reduced folate carrier; single nucleotide polymorphism; autism spectrum disorder; insulin receptor substrate; single nucleotide polymorphism; insulin-like growth factor; childhood autism; non-syndromic; transcriptome; saliva; reverse transcriptase quantitative real-time PCR (RT-qPCR); housekeeping genes (HKGs); reference gene; stability of expression; geNorm; NormFinder; autism; genetics; neuroligins; SNPs; haplotype analysis; noncoding regions; chromosomal microarray; copy number variants; neurodevelopmental disorders; autism spectrum disorder; variants of unknown significance; FirstStepDx PLUS; Prader-Willi syndrome; PWS; social communication; Autism Diagnostic Observation Schedule; ADOS; autism spectrum disorder; ASD; mental illness; genetic profiling; GeneAnalytics molecular pathway analysis; circadian entrainment; autism; genetic disorders; hierarchical diagnostic strategy; child psychiatric and psychological assessment; clinical genetics; neuropediatric evaluation; mTORC1 signaling pathway; ASD-related syndromes and nonsyndromic/idiopathic ASD; neuronal cell growth; axonal and dendritic morphogenesis; dendritic spine density and maturation; synaptic plasticity; mTORC1-targeted therapies; autism spectrum disorder (ASD); index finger abduction; force variability; motorneuron pool; first dorsal interosseus (FDI) muscle; decomposition-based electromyography (dEMG); ASD; autism; networks; genetics; Fragile-X Syndrome; Wnt; mTOR; Calmodulin; Calcium; NGF; neurotransmission; excitation and inhibition balance; cognitive delay; prefrontal cortex; neuroligins; clock genes; circadian rhythm; circadian clocks network; synchronization of oscillators; sleep-wake rhythm; psychiatric disorders; schizophrenia; autism spectrum disorder; mood disorders; attention deficit hyperactivity disorder; ASD; autism; Asperger syndrome; clinical genetic testing; parents; attitudes; ethics; genetic counselling; 22q11.2 deletion; autism; autism spectrum; diagnosis; copy number variation; CNV; Research Domain Criteria; RDoC; autism spectrum disorder; creatine deficiency syndrome; glycine amidinotransferase; guanidinoacetate methyltransferase; solute carrier family 6 member 8; genetic variability