Reprint

Mitochondrial Dysfunction in Aging and Diseases of Aging

Edited by
September 2019
268 pages
  • ISBN978-3-03921-327-6 (Paperback)
  • ISBN978-3-03921-328-3 (PDF)

This book is a reprint of the Special Issue Mitochondrial Dysfunction in Aging and Diseases of Aging that was published in

Biology & Life Sciences
Summary

This collection of review articles authored by international experts pulls together current information about the role of mitochondria in aging and diseases of aging. Mitochondria are vitally important cellular organelles and undergo their own aging process becoming less efficient in aged animals including humans. These changes have wide-ranging significance contributing to immune dysfunction (autoimmunity and immune deficiency), inflammation, delayed healing, skin and retinal damage, cancer and most of the degenerative diseases of aging. Mitochondrial aging predisposes to drug toxicity in the geriatric population and to many of the features of normal aging. The research detailed in this book summarizes current understanding of the role of mitochondria in the complex molecular changes of aging, moving on to specific diseases of aging. Mitochondrial dysfunction is an important target for development of treatments for aging and disease. The last article details how exercise is a treatment and combats many features of the aging process. 

Format
  • Paperback
License
© 2019 by the authors; CC BY-NC-ND licence
Keywords
aging; mitochondria; inflammation; innate immunity; adaptive immunity; immunosenescence; cell danger response; healing cycle; mitochondria; purinergic signaling; metabokines; sphingolipids; integrated cell stress response; de-emergence; crabtree effect; pasteur effect; coenzyme Q10; aging; age-related diseases; mitochondrial dysfunction; mitochondria; skin; ageing; reactive oxygen species; photoageing; 25(OH)D; 1,25(OH)2D; aging; cytokines; inflammation; morbidity and mortality; prevention; reactive oxygen species; ultraviolet; aging; mitochondria; retina; optic nerve; diabetic retinopathy; age-related macular degeneration; glaucoma; drug-induced mitochondrial toxicity; polypharmacy; aging; mitochondrial dysfunction; insulin resistance; type 2 diabetes; mitochondrial transfer; exosomes; mitochondrial; genetic mutations; cardiovascular disease; heart failure; cardiomyopathy; mitochondria; cancer; nucleotide metabolism; DNA damage; NAD+; mitochondria; ALS; axonal transport; mitophagy; SOD1; Miro1; PINK1; Parkin; multiple sclerosis; mitochondria; neuroinflammation; neurodegeneration; Parkinson’s disease; mitochondria; ageing; neurodegenerative disease; Alzheimer’s disease; eIF2α; metabolism; mitochondria; proteostasis; stress response; aging; exercise; mitochondria; aerobic; ROS; inflammation; senescence; lysosome; autophagy; mitophagy; n/a