Reprint
Hedgehog Signaling in Organogenesis and Tumor Microenvironment
Edited by
October 2020
172 pages
- ISBN978-3-03936-260-8 (Hardback)
- ISBN978-3-03936-261-5 (PDF)
This book is a reprint of the Special Issue Hedgehog Signaling in Organogenesis and Tumor Microenvironment that was published in
Biology & Life Sciences
Chemistry & Materials Science
Medicine & Pharmacology
Summary
The Hedgehog signaling pathway is an evolutionarily conserved pathway that governs complex developmental processes, including stem cell maintenance, proliferation, differentiation, and patterning. Several recent studies have shown that the aberrant activation of Hedgehog signaling is associated with neoplastic transformation, cancer cell proliferation, metastasis, multiple cancers’ drug resistance, and survival rates. This book focuses on several aspects of Hedgehog signaling in organogenesis and the tumor microenvironment, and presents reviews and original papers on recent efforts in the field of Hedgehog signaling.
Format
- Hardback
License
© 2020 by the authors; CC BY-NC-ND license
Keywords
Cyp26 enzymes; congenital anomalies; CRE/LoxP; hedgehog signaling; mouse models; retinoic acid; smoothened; sonic hedgehog; sonic hedgehog (SHH); oral squamous cell carcinoma (OSCC); tumor microenvironment (TME); tumor-associated macrophages (TAMs); cancer-associated fibroblasts (CAFs); tumor-associated angiogenesis; hedgehog; growth plate; endochondral ossification; chondrocyte; osteoblast; bone disease; TMJ; synovial joint; articular disc; Ihh; PTHrP; osteoarthritis; hedgehog; epithelial–mesenchymal interaction (EMI); prostate cancer; external genitalia; androgen; basement membrane; bone morphogenetic protein; sonic hedgehog; stem cell; animal experiment; fracture healing; hedgehog; smoothened; cancer stem cells; hypospadias; urethra; penis; bone; hedgehog signalling; sonic hedgehog; tooth development; epithelial and mesenchymal interaction; Gli1; mesenchymal stem cell; lineage tracing analysis; stem cell marker; n/a