Genetic Diversity Assessment and Marker-Assisted Selection in Ruminants Livestock

A special issue of Agriculture (ISSN 2077-0472). This special issue belongs to the section "Farm Animal Production".

Deadline for manuscript submissions: closed (20 March 2022) | Viewed by 2760

Special Issue Editor

The Key Laboratory for Farm Animal Genetic Resources and Utilization, Ministry of Agriculture and Rural Affairs, Institute of Animal Science Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, China
Interests: genomic selection; molecular breeding; population genomics; functional genetics; economic traits; genomic diversity; genome-wide association analysis; transcriptome analysis; integrated genomic analysis

Special Issue Information

Dear Colleagues,

There are more than 1500 breeds of ruminants worldwide, representing a huge amount of phenotype diversity in growth, fertility, and the production of meat, milk, and wools. This provided us with ideal animal models to assess the genetic diversity and identify the functional genes or genetic markers correlated with these traits of economic value. Theoretical and simulation studies show that the advantage of using marker-assisted selection can be substantial, particularly when marker information is used, because normal selection is less effective, for example, for sex-limited or carcass traits. Emerging genomic technologies could allow large numbers of polymorphic sites to be identified. This type of approach, combined with cheap and high density markers, could largely facilitate the breeding process in ruminants livestock. Therefore, this Special Issue aims to report on recent studies in genetic/genomic diversity assessment, functional genes/markers identification and marker-assisted selection in ruminant livestock, including cow, cattle, yak, buffalo, sheep, goat, camel and so on.

Dr. Lin Jiang
Guest Editor

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Keywords

  • ruminant breeding
  • genetic/genomic diversity
  • functional genes/markers identification
  • marker-assisted selection (MAS)
  • genomic selection (GS)

Published Papers (1 paper)

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Research

14 pages, 2341 KiB  
Article
Transcriptome Analysis Reveals Candidate Genes Regulating the Skin and Hair Diversity of Xinji Fine-Wool Sheep and Tan Sheep
by Tianyou Bai, Benmeng Liang, Yuhetian Zhao, Jiangang Han, Yabin Pu, Chunxin Wang, Yuehui Ma and Lin Jiang
Agriculture 2022, 12(1), 15; https://0-doi-org.brum.beds.ac.uk/10.3390/agriculture12010015 - 23 Dec 2021
Cited by 3 | Viewed by 2432
Abstract
The hair follicle is a complex mini-organ in the skin that undergoes organ induction, morphogenesis, and regeneration. However, the accurate molecular mechanism of skin and hair diversity regulation is still elusive. The sheep is an animal model that can be used to further [...] Read more.
The hair follicle is a complex mini-organ in the skin that undergoes organ induction, morphogenesis, and regeneration. However, the accurate molecular mechanism of skin and hair diversity regulation is still elusive. The sheep is an animal model that can be used to further explore the mechanisms of skin and hair diversity. In this study, we carried out a transcriptomic analysis of the mRNA expression in the skin of Xinji fine-wool sheep at different growth stages (3 and 12 months old) and 12-month-old Tan sheep and explored the transcripts’ relationship with hair follicle growth. A total of 1327 mRNAs and 67 transcription factors were identified to be differentially expressed in the different breeds and during different periods of skin development. The differentially expressed genes were enriched in GO terms represented by system development, multicellular organism development, animal organ development, and skin development, and three KEGG pathways typified those governing differences in skin structure. Combining protein–protein interaction networks of skin development (GO:0043588) and functional annotation, nine important candidate genes, namely, LAMA5, OVOL1, SRF, DHCR24, NGFR, SMO, CDSN, HOXC13, and KDF1, and many core genes with minor effects were confirmed to be associated with hair follicle development. Furthermore, members of the zf-C2H2 and homeobox transcription factor families, which were identified to play a crucial role in producing finer and denser wool, were mainly upregulated in 12-month-old Xinji fine-wool sheep when compared with expression in 12-month-old Tan sheep and 3-month-old Xinji fine-wool sheep. This study revealed the major–minor gene interactions in the developmental pathway and provided ideas for an in-depth understanding of the genetic structure and gene regulation in the skin/hair growth process. Full article
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