Special Issue "Emerging and Re-Emerging Fish and Shellfish Viruses - Special Issue Dedicated to Dr. James R. Winton"

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Aquatic Animals".

Deadline for manuscript submissions: 30 November 2021.

Special Issue Editors

Prof. Mohamed Faisal
E-Mail Website
Guest Editor
Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine and Department of Fisheries and Wildlife, College of Agriculture and Natural Resources, Michigan State University, East Lansing, MI, USA
Interests: diseases of aquatic animals
Dr. Jun Li
E-Mail Website
Guest Editor
School of Science and Medicine, Lake Superior State University, Sault Ste. Marie, MI 49783, USA
Interests: fish diseases; innate and adaptive immunity; host-pathogen interaction; vaccine and immunostimulants development; diagnosis of diseases; epidemic survey; pathogenic mechanisms of infectious diseases; environmental impacts on fish health
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Special Issue Information

Dear colleagues,

As many of you are aware, Dr. James R. Winton of the United States Geological Service Western Fisheries Research Center, Seattle, Washington has recently retired after a remarkable career in fish health research and management that focused on fish viruses. We, his students, friends, colleagues, and collaborators are assembling this Special Issue on emerging and re-emerging fish and shellfish viruses as a tribute to his outstanding career. Dr. Winton’s remarkable achievements are summarized in his curriculum vitae click here. text
Emerging and re-emerging fish and shellfish viral infections present a substantial impediment to fishery conservation, sustainability, and farming. What led to the emergence of these serious pathogens? What is the extent of the losses they can cause to the environment and fishery recruitment? What is the best management strategy to control the spread of these viruses and mitigate their effects? These and many more related questions are currently without answers. It is well known, however, that these emerging fish viruses are mostly novel, i.e., were never described, while others have re-emerged in a mutated form, as revealed by deep transcriptome sequencing. Overwhelmed by the current situation, fishery managers and scientists are anxious to decipher the nature of emerging viruses, their reservoirs, modes of transmission, as well as potential targets for drug discovery and vaccine development.
We would like to invite you to contribute to Dr. Winton’s Special Issue by submitting a research paper, review article, or short communication that further our understanding of fish and shellfish viruses’ pathogenicity, immunology, epidemiology, improved diagnostics, newly developed vaccines, taxonomy, and host susceptibility.

Prof. Mohamed Faisal
Dr. Jun Li
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • fish and shellfish viruses
  • host-pathogen intricacies
  • emerging viral infections
  • development of novel diagnostic assays
  • fish virus immunology
  • vaccine development.

Published Papers (1 paper)

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Different Immune Responses of the Lymphoid Organ in Shrimp at Early Challenge Stage of Vibrio parahaemolyticus and WSSV
Animals 2021, 11(8), 2160; https://0-doi-org.brum.beds.ac.uk/10.3390/ani11082160 - 21 Jul 2021
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The lymphoid organ is an essential part of the immune system involved in cellular and humoral immune responses in shrimp. However, its roles in the immune responses against different pathogens are still largely unclear. In the present study, transcriptomic analysis was applied to [...] Read more.
The lymphoid organ is an essential part of the immune system involved in cellular and humoral immune responses in shrimp. However, its roles in the immune responses against different pathogens are still largely unclear. In the present study, transcriptomic analysis was applied to compare the differentially expressed genes (DEGs) in the lymphoid organ of shrimp after Vibrio or WSSV challenge. In total, 2127 DEGs were screened in the lymphoid organ of shrimp at 6 h post Vibrio parahaemolyticus injection, and 1569 DEGs were obtained at the same time after WSSV challenge. KEGG pathway enrichment analysis of these DEGs revealed that two significantly enriched pathways including “neuroactive ligand–receptor interaction” and “protein digestion and absorption” were responsive to both pathogens. In contrast, “lysosome” was the significantly enriched pathway only in Vibrio challenge whereas carbohydrate metabolism related pathways were the significantly enriched pathways only in WSSV challenge. Further analysis on immune-related DEGs showed that Vibrio challenge induced broad immune responses in the lymphoid organ including activation of several pattern recognition receptors, the proPO activating system, phagocytosis related genes, and immune effectors. In contrast, the immune responses seemed to be inhibited after WSSV infection. The data suggest that the shrimp lymphoid organ plays different functions in response to the infection of distinct pathogens at the early stage, which provides new insights into the immune functions of lymphoid organ in shrimp. Full article
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