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Animals
Special Issues
Uterine Meaning in Diseases of Animals
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Uterine Meaning in Diseases of Animals

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Veterinary Clinical Studies".

Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 4820

Special Issue Editor

Dr. Anna. J. Korzekwa

E-Mail Website
Guest Editor
Department of Biodiversity Protection, Institute of Animal Reproduction and Food Research Polish Academy of Sciences in Olsztyn, 10-748 Olsztyn, Poland
Interests: reproductive biology; immunology; nutrition; welfare; heterogeneity of domestic and wild ruminants
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The origin of reproductive tract diseases in farm and domestic animals is associated with systemic inflammatory processes or inflammations within the reproductive organs. The influence of nutrition on the condition of the organism, including the proper course of female reproductive processes, is very important. Some genetic predisposition also plays a role in uterine diseases. Depending on the species, it is known that a disturbed maternal transmission system and uterine environment may contribute to dysfunction during pregnancy at various stages.

In farm animals, persistent diseases within the reproductive system—including the uterus—cause economic losses in breeding in the long-term balance. On the other hand, the knowledge of molecular factors and signaling pathways induced during uterine endometrium and myometrium dysfunction in selected species may constitute a research model for female diseases.

This Research Topic is gathering original research, reviews, brief research reports, and case reports.

Dr. Anna. J. Korzekwa
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • uteum
  • uterus
  • adenomyosis
  • cytokines
  • arachidonic acid metabolites
  • pregnancy

Published Papers (2 papers)

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Research

14 pages, 3249 KiB  
Article
Steroid Receptor Coregulators Can Modulate the Action of Progesterone Receptor during the Estrous Cycle in Cow Endometrium
by Robert Rekawiecki, Karolina Dobrzyn and Magdalena K. Kowalik
Animals 2021, 11(11), 3217; https://0-doi-org.brum.beds.ac.uk/10.3390/ani11113217 - 10 Nov 2021
Cited by 1 | Viewed by 1576
Abstract
Nuclear receptor coregulators include coactivators and corepressors which associate with the progesterone receptor (PGR) during its activation. Fluctuations in the transcription levels of their respective genes and subsequent protein production as well as in related activities for histone acetyltransferase (HAT) and histone deacetylase [...] Read more.
Nuclear receptor coregulators include coactivators and corepressors which associate with the progesterone receptor (PGR) during its activation. Fluctuations in the transcription levels of their respective genes and subsequent protein production as well as in related activities for histone acetyltransferase (HAT) and histone deacetylase (HDAC) can affect PGR function and thus change the action of progesterone (P4) in bovine endometrium during the estrous cycle. Endometrial tissue on days 2–5, 6–10, 11–16, and 17–20 of the estrous cycle was used for determination of the mRNA expression levels of coactivators P300, CREB, and SRC-1 along with corepressor NCOR-2 using Real-Time PCR, with protein levels by Western blot. Coregulators cellular localizations were assessed by immunohistochemistry whereas the activities of HAT and HDAC by using EIA. The highest levels of mRNA and proteins for all of the investigated coregulators, as well as the highest levels of activity for HAT and HDAC, were detected over days 2–16 of the estrous cycle. All of the tested coregulatory proteins were localized in the nuclei of endometrial cells. This research indicates the important role of coregulators of the PGR receptor in regulating P4 activity in endometrial cells, especially during the pre-implantation period. Full article
(This article belongs to the Special Issue Uterine Meaning in Diseases of Animals)
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14 pages, 2107 KiB  
Article
Expression of Transforming Growth Factor Beta Isoforms in Canine Endometrium with Cystic Endometrial Hyperplasia–Pyometra Complex
by Marta Rybska, Magdalena Woźna-Wysocka, Barbara Wąsowska, Marek Skrzypski, Magdalena Kubiak, Beata Błaszak, Anna Łukomska, Tomasz Nowak and Jędrzej M. Jaśkowski
Animals 2021, 11(6), 1844; https://0-doi-org.brum.beds.ac.uk/10.3390/ani11061844 - 21 Jun 2021
Cited by 4 | Viewed by 2520
Abstract
Cystic endometrial hyperplasia (CEH) and pyometra are the most frequently diagnosed uterine diseases affecting bitches of different ages. Transforming growth factor beta (TGF-β) has been classified in females as a potential regulator of many endometrial changes during the estrous cycle or may be [...] Read more.
Cystic endometrial hyperplasia (CEH) and pyometra are the most frequently diagnosed uterine diseases affecting bitches of different ages. Transforming growth factor beta (TGF-β) has been classified in females as a potential regulator of many endometrial changes during the estrous cycle or may be involved in pathological disorders. The aim of this study was to determine the expression of TGF-β1, -β2 and -β3 in the endometrium of bitches suffering from CEH or a CEH–pyometra complex compared to clinically healthy females (control group; CG). A significantly increased level of TGF-β1 mRNA expression was observed in the endometrium with CEH–pyometra compared to CEH and CG. Protein production of TGF-β1 was identified only in the endometrium of bitches with CEH–pyometra. An increase in TGF-β3 mRNA expression was observed in all the studied groups compared to CG. The expression of TGF-β2 mRNA was significantly higher in CEH and lower in CEH–pyometra uteri. The results indicate the presence of TGF-β cytokines in canine endometrial tissues affected by proliferative and degenerative changes. However, among all TGF-β isoforms, TGF-β1 could potentially be a key factor involved in the regulation of the endometrium in bitches with CEH–pyometra complex. Full article
(This article belongs to the Special Issue Uterine Meaning in Diseases of Animals)
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